Evidence map›Paper›PMID 32157427›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

Interobserver variability, detection rate, and lesion patterns of

Jonathan Miksch, Dirk Bottke, Thomas Krohn, Reinhard Thamm, Detlef Bartkowiak, Christoph Solbach, Christian Bolenz, Meinrad Beer, Thomas Wiegel, Ambros J Beer and 1 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 5 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Frontiers in oncology · 2023
    Pooled it
  5. European journal of nuclear medicine and molecular imaging · 2022
    Pooled it
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  15. A VISION Substudy of Reader Agreement onJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
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  16. Detection Efficacy ofCancers · 2023
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  17. SkeletalTherapeutic advances in medical oncology · 2023
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  18. Article
  19. Diagnostic Performance and Clinical Impact ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  20. Value of PET imaging for radiation therapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Jonathan MikschDepartment of Nuclear Medicine, University Hospital of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany. jonathan.miksch@uniklinik-ulm.de.ORCID 0000-0002-0121-0179
Dirk BottkeDepartment of Radiation Oncology, University Hospital of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Thomas KrohnDepartment of Nuclear Medicine, University Hospital of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Reinhard ThammDepartment of Radiation Oncology, University Hospital of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Detlef BartkowiakDepartment of Radiation Oncology, University Hospital of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Christoph SolbachDepartment of Nuclear Medicine, University Hospital of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Christian BolenzDepartment of Urology, University Hospital of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Meinrad BeerDepartment of Radiology, University Hospital of Ulm , Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Thomas WiegelDepartment of Radiation Oncology, University Hospital of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Ambros J BeerDepartment of Nuclear Medicine, University Hospital of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Vikas PrasadDepartment of Nuclear Medicine, University Hospital of Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
University Hospital Ulm · DEKlinikum Esslingen · DELandeskriminalamt Niedersachsen · DEUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose

methodsWe analyzed

resultsThe overall detection rate (categories 4 and 5) was 50% (R1/R2, 49%/51%) and in the PSA subgroups 0-0.2 ng/ml, 0.21-0.3 ng/ml, and 0.31-0.6 ng/ml 24%/27%, 57%/57%, and 65%/68%, respectively. Local recurrence was the most common lesion manifestation followed by lymphatic and bone metastases. The overall agreement in the Cohens Kappa analysis was 0.74 between R1 and R2. For local, lymphatic, and bone sites, the agreement was 0.76, 0.73, and 0.58, respectively. PSA levels of PSMA PET/CT-positive patients after salvage treatment decreased in 75% (27/36) and increased in 25% (9/36). A decrease of PSA, although more frequent in patients with imaging suggesting only local tumor recurrence (86%, 18/21), was also observed in 67% (10/15) of patients with findings of metastatic disease.

conclusionsIn a highly homogeneous group of prostate cancer patients with early-stage biochemical recurrence after radical prostatectomy, we could show that

Indexed as

Positron Emission Tomography Computed TomographyProstatic NeoplasmsEdetic AcidGallium IsotopesGallium RadioisotopesHumansMaleNeoplasm Recurrence, LocalObserver VariationOligopeptidesProstatectomyProstate-Specific AntigenRecurrenceEdetic Acidgallium 68 PSMA-11Gallium IsotopesGallium RadioisotopesOligopeptidesProstate-Specific AntigenBiochemical recurrenceLow PSAPET/CTProstate cancerProstatectomyPSMA

Identifiers

PMID32157427
PMCPMC7396406
OpenAlexW3012305372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.