ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2020
Characteristics of vertebral CT Hounsfield units in elderly patients with acute vertebral fragility fractures.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
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37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Risk factors for new vertebral compression fracture following percutaneous vertebral augmentation: a systematic review and meta-analysis based on multivariate logistic regression analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Comparative effectiveness of four techniques for identifying vertebral fragility fractures among elderly patients.European radiology · 2025Pooled it
- CT image-based biomarkers for opportunistic screening of osteoporotic fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Pooled it
- Osteoporotic Fractures of the Thoracic and Lumbar Vertebrae: Diagnosis and Conservative Treatment.Deutsches Arzteblatt international · 2021Pooled it
- Multilevel Lumbar CT Attenuation Beyond L1: Comparison with QCT-Derived Volumetric Bone Mineral Density and Prevalent Fragility Fracture Status in a Diagnostic Referral Cohort.Diagnostics (Basel, Switzerland) · 2026Article
- Hounsfield unit measurements from different regions of interest in lumbar spine CT: correlation with DEXA-derived bone mineral density and fracture status.BMC musculoskeletal disorders · 2026Article
- Which vertebral levels provide practical HU-based assessment for osteoporosis screening? A comparative analysis from T1 to S2.Journal of orthopaedic surgery and research · 2026Article
- Comparison between Hounsfield unit value and vertebral bone quality score for adjacent vertebral fracture risk assessment after balloon kyphoplasty: a propensity score matching study.Asian spine journal · 2026Article
- Clinical Characteristics and a New Classification System of Mono-Segmental Thoracic and Lumbar Nonfusion in Patients With Ankylosing Spondylitis.Orthopaedic surgery · 2026Article
- Evaluating Bone Mass with Opportunistic Chest CT: T8 as the Optimal Vertebral Level.Calcified tissue international · 2025Article
- Vertebral bone density variation and site-specific computed tomography measurements for risk of subsequent fracture post-cement augmentation: a retrospective study.Quantitative imaging in medicine and surgery · 2025Article
- Vertebral CT Hounsfield units in postmenopausal women with osteoporotic vertebral compression fracture: identification and validation of reference intervals.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Opportunistic Osteoporosis Assessment and Fracture Risk Determination Using Cancellous Density Measurement in Hounsfield Units of Native Lumbar Computed Tomography Images-A Comparative Study with Conventional Bone Density Evaluation.Journal of clinical medicine · 2025Article
- Evaluation of Cancellous Bone Density from C3 to L5 in 11 Body Donors: CT Versus Micro-CT Measurements.Journal of clinical medicine · 2025Article
- Percutaneous endoscopic treatment for osteoporotic vertebral compression fracture complicated with lumbar spinal stenosis: a case report and literature review.Frontiers in medicine · 2025Article
- Answer to the letter to the editor of H. Hirata, et al. concerning "Osteoporosis screening using QCT-based cutoff values of Hounsfield units in patients with degenerative lumbar diseases" by D. Zou, et al. (Eur Spine J [2024]: doi: 10.1007/s00586-024-08491-4).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Correlation analysis of osteoporosis and vertebral endplate defects using CT and MRI imaging: a retrospective cross-sectional study.Frontiers in physiology · 2025Article
- Regional variations and spatial heterogeneity of lumbar CT attenuation are associated with osteoporotic vertebral fracture.Frontiers in endocrinology · 2025Article
- Unsupervised Clustering of Vertebral Hounsfield Units in Opportunistic Chest CT for Stratifying Bone Mass Subtypes in a 2 Years' Period.Clinical interventions in aging · 2025Article
- Evaluating bone mineral density in osteoporotic vertebral compression fractures: the clinical utility of anterior column Hounsfield units.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the characteristics of vertebral CT Hounsfield units (HU) in elderly patients with acute vertebral fragility fractures.
methodsA total of 299 patients aged ≥ 65 years with acute vertebral fragility fractures were retrospectively reviewed, and 77 patients of them were age- and sex-matched with 77 control patients without any fractures. The vertebral HU value of L1(L1-HU) was measured, and T12 and L2 were used as alternatives for L1 in the case of L1 fracture.
resultsThere were 460 thoracic and lumbar vertebral fractures in the 299 elderly patients, including 349 acute vertebral fragility fractures and 111 chronic fractures. The average L1-HU value was 66.0 ± 30.6 HU and showed significant difference among patients having different numbers of vertebral fractures (one fracture: 73.3 ± 27.0 HU, two fractures: 58.7 ± 32.5 HU, three or more fractures: 40.7 ± 28.8 HU; P < 0.001). As for the 1:1 age- and sex-matched patients, the L1-HU of the 77 patients with fractures was lower than that of the control patients (70.6 ± 23.4 HU vs. 101.5 ± 36.2 HU, P < 0.001). The area under the receiver operating characteristic curve of using L1-HU to differentiate patients with fractures from controls was 0.77(95% CI 0.70-0.85, P < 0.001). The cutoff value had high specificity of 90% or high sensitivity of 90% to identify patients with fractures of 60 HU and 100 HU, respectively.
conclusionsThe elderly patients with acute vertebral fragility fractures have much lower HU values than those without fractures. Moreover, the lower the vertebral HU value is, the more likely the patients have more than one vertebral fracture. These slides can be retrieved under Electronic Supplementary Material.
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