ArticleJournal of mathematical biology2020
Infection severity across scales in multi-strain immuno-epidemiological Dengue model structured by host antibody level.
Article in Journal of mathematical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.
- Mathematical models for dengue fever epidemiology: A 10-year systematic review.Physics of life reviews · 2022Pooled it
- Within-host models unravelling the dynamics of dengue reinfections.Infectious Disease Modelling · 2024Article
- The effect of model structure and data availability on Usutu virus dynamics at three biological scales.Royal Society open science · 2024Article
- Knowledge, attitudes and practices of dengue prevention between dengue sustained hotspots and non-sustained hotspots in Singapore: a cross-sectional study.Scientific reports · 2022Article
- Sensitivity Analysis in an Immuno-Epidemiological Vector-Host Model.Bulletin of mathematical biology · 2022Article
- Tracing the footsteps of autophagy in computational biology.Briefings in bioinformatics · 2021Article
- Data-driven methods for present and future pandemics: Monitoring, modelling and managing.Annual reviews in control · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection by distinct Dengue virus serotypes and host immunity are intricately linked. In particular, certain levels of cross-reactive antibodies in the host may actually enhance infection severity leading to Dengue hemorrhagic fever (DHF). The coupled immunological and epidemiological dynamics of Dengue calls for a multi-scale modeling approach. In this work, we formulate a within-host model which mechanistically recapitulates characteristics of antibody dependent enhancement in Dengue infection. The within-host scale is then linked to epidemiological spread by a vector-host partial differential equation model structured by host antibody level. The coupling allows for dynamic population-wide antibody levels to be tracked through primary and secondary infections by distinct Dengue strains, along with waning of cross-protective immunity after primary infection. Analysis of both the within-host and between-host systems are conducted. Stability results in the epidemic model are formulated via basic and invasion reproduction numbers as a function of immunological variables. Additionally, we develop numerical methods in order to simulate the multi-scale model and assess the influence of parameters on disease spread and DHF prevalence in the population.
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