ArticleInternational journal of colorectal disease2020
Incidence, risk factors, treatment, and survival of ovarian metastases of colorectal origin: a Dutch population-based study.
Article in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Ovarian metastases from colorectal cancer in young women: a systematic review of the literature.International journal of colorectal disease · 2021Pooled it
- Molecular Characterization of Ovarian Metastases from Colorectal Cancer Using Circulating Tumor DNA Analysis.JMA journal · 2026Article
- Histopathological assessment to detect colorectal ovarian micrometastasis following prophylactic salpingo-oophorectomy in postmenopausal patients.International journal of colorectal disease · 2026Article
- Perioperative Outcomes of Postmenopausal Women with Colorectal Cancer Undergoing Prophylactic Salpingo-oophorectomy.South Asian journal of cancer · 2025Article
- The heterogeneity of genomic alterations, metastatic patterns and immune microenvironment in metastatic ovarian cancer originating from colorectal cancer.Frontiers in immunology · 2025Article
- Early Detection of Krukenberg Tumors Utilizing ctDNA Testing and CEA Monitoring.Case reports in oncological medicine · 2025Article
- How to differentiate primary mucinous ovarian tumors from ovarian metastases originating from primary appendiceal mucinous neoplasms: a review.Pathology oncology research : POR · 2025Review
- Impact of resection for ovarian metastases from colorectal cancer and clinicopathologic analysis: A multicenter retrospective study in Japan.Annals of gastroenterological surgery · 2024Article
- Prediction of Chemotherapy Efficacy in Patients with Colorectal Cancer Ovarian Metastases: A Preliminary Study Using Contrast-Enhanced Computed-Tomography-Based Radiomics.Diagnostics (Basel, Switzerland) · 2023Article
- Role Of Ovarian Metastases In Colorectal Cancer (ROMIC): a Dutch study protocol to evaluate the effect of prophylactic salpingo-oophorectomy in postmenopausal women.BMC women's health · 2022Article
- Ovarian metastases in young women with colorectal cancer: a retrospective multicenter cohort study.International journal of colorectal disease · 2022Article
- The clinicopathological characteristics, prognosis, and CT features of ovary metastasis from colorectal carcinoma.Translational cancer research · 2021Article
- Prognosis and factors affecting colorectal cancer with ovarian metastasis.Updates in surgery · 2021Review
- Prognostic significance of ovarian metastases (macroscopic or microscopic) in patients with colorectal cancer undergoing cytoreduction followed by HIPEC.International journal of colorectal disease · 2020Article
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7 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this nationwide study was to provide insight in the incidence, risk factors, treatment, and survival of patients with ovarian metastases from colorectal cancer (CRC).
methodsData from the Netherlands Cancer Registry were used. All newly diagnosed female CRC patients between 2008 and 2016 were included. Treatment was categorized as follows: cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (CRS-HIPEC); resection of the primary tumor; palliative treatment; and no treatment. Overall survival (OS) was investigated using Kaplan-Meier and multivariable Cox regression analyses.
resultsOf 53,883 female CRC patients, 11,343 (21.1%) had metastases at time of diagnosis. Among them, 471 (4.2%) had ovarian metastases. Within latter group, 27.2% received CRS-HIPEC; 38.4% underwent resection of the primary tumor; 25.3% received palliative treatment; and 9.1% received no treatment. Median OS of all patients with ovarian metastases was 17.5 months. In patients receiving CRS-HIPEC, OS was significantly longer than in patients undergoing resection only (median OS 34.1 vs. 17.5 months, adjusted HR 0.44 [0.33-0.66]). Five-year OS was 28.5% for patients having underwent CRS-HIPEC, 11.0% for patients having underwent resection of the primary tumor, 1.2% for patients having underwent palliative treatment, and 0.0% for patients without treatment.
conclusionsSynchronous ovarian metastases are diagnosed in 4.2% of female colorectal patients presenting with metastatic disease. Risk factors are young age, T4/N+ tumor and histology of signet ring cell carcinoma. Median OS of the entire cohort was 17.5 months, ranging from 3.1 months in patients without treatment to 34.1 months in patients undergoing CRS-HIPEC.
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