ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2020
Time to diagnosis and clinical characteristics in pediatric brain tumor patients.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 29 citations in OpenAlex.
- Suprasellar CNS germ cell tumors and endocrine sequelae: early growth hormone therapy as a contributor to height gain: a single institute analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Impact of the COVID-19 pandemic on referral practices for pediatric central nervous system tumors: A Danish National Comparative Cohort Study.Neuro-oncology practice · 2025Article
- Delay in the diagnosis of pediatric central nervous system tumors: data from a single tertiary care center.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Patterns, clinical presentations, and time to diagnosis in pediatric central nervous system tumors: insights from a pediatric neuro-oncology tumor board team at a tertiary referral hospital in Ethiopia.Journal of neuro-oncology · 2025Article
- Nanotechnology in brain cancer treatment: The role of gold nanoparticles as therapeutic enhancers.Ibrain · 2025Review
- Unlocking delays: revealing barriers to early diagnosis of childhood central nervous system tumors in an upper-middle-income country.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Hjernetegn.dk-The Danish Central Nervous System Tumor Awareness Initiative Digital Decision Support Tool: Design and Implementation Report.JMIR medical informatics · 2024Article
- Feasibility of Augmented Reality for Pediatric Giant Supratentorial Tumors: A Report of Three Cases.Cureus · 2024Article
- Musculoskeletal misdiagnoses in children with brain tumors: A nationwide, multicenter case-control study.PloS one · 2023Article
- Prognostic factors of pediatric ependymomas at a National Cancer Reference Center in Peru.Frontiers in oncology · 2023Article
- Ethnic and socioeconomic disparities in survival of children and adolescents with CNS tumors in Southern Israel.Neuro-oncology practice · 2022Article
- Factors associated with delayed diagnosis among Filipino pediatric brain tumor patients: a retrospective review.CNS oncology · 2022Article
- Giant Pediatric Supratentorial Tumor: Clinical Feature and Surgical Strategy.Frontiers in pediatrics · 2022Article
- Presenting symptoms and time to diagnosis for Pediatric Central Nervous System Tumors in Qatar: a report from Pediatric Neuro-Oncology Service in Qatar.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- PBTNet: A New Computer-Aided Diagnosis System for Detecting Primary Brain Tumors.Frontiers in cell and developmental biology · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe aimed to identify factors that affect the time to diagnosis in pediatric brain tumors and investigate the effect of time to diagnosis on clinical outcome.
methodsA retrospective study of children with brain tumors aged less than 18 years diagnosed at the University of Tsukuba Hospital over a period of 7 years was conducted.
resultsEighty-five consecutive patients, with a mean age of 9.1 years, were included in the study. The median interval from symptom onset to diagnosis was 45 days (range 0-1673); median interval from symptom onset to first presentation was 31.0 days; and median interval from first presentation to diagnosis was 13.5 days. Germinoma had the longest interval from symptom onset to first presentation, and from first presentation to diagnosis. Patients presenting with endocrine disorder had a significantly longer interval from symptom onset to first presentation (p = 0.019); those with visual disturbance (p = 0.016) or endocrine disorder (p = 0.030) had significantly longer intervals from first presentation to diagnosis.
conclusionPediatric brain tumor patients with germinoma and presenting symptoms of endocrine disorder or visual disturbance have a longer time to diagnosis. Although improved prognosis is not clearly related to a shorter time to diagnosis, we believe that early diagnosis can lead to improved treatment and better quality of life. A detailed medical history and neuroimaging studies at the earliest time possible are important for early diagnosis.
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