Evidence map›Paper›PMID 32157317›Full record

ArticleCellular and molecular life sciences : CMLS2021

Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue.

Tiziana Caputo, Van Du T Tran, Nasim Bararpour, Carine Winkler, Gabriela Aguileta, Khanh Bao Trang, Greta M P Giordano Attianese, Anne Wilson, Aurelien Thomas, Marco Pagni and 3 more

Abstract read
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In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. The regulation of adipocyte growth in white adipose tissue.Frontiers in cell and developmental biology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tiziana CaputoCenter for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Van Du T TranVital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Nasim BararpourUnit of Forensic Toxicology and Chemistry, CURML, Lausanne University Hospital, Geneva University Hospitals, Lausanne, Switzerland.
Carine WinklerCenter for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Gabriela AguiletaCenter for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Khanh Bao TrangCenter for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Greta M P Giordano AttianeseCenter for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
Anne WilsonDepartment of Oncology, University of Lausanne, Epalinges, Switzerland.
Aurelien ThomasUnit of Forensic Toxicology and Chemistry, CURML, Lausanne University Hospital, Geneva University Hospitals, Lausanne, Switzerland.
Marco PagniVital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Nicolas GuexVital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Béatrice DesvergneCenter for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. beatrice.desvergne@unil.ch.
Federica GilardiCenter for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. federica.gilardi@chuv.ch.ORCID http://orcid.org/0000-0001-5421-2779

Funding

Swiss National Science Foundation (CH) 310030_156771
6 · The paper itself

Abstract

Chronic inflammation that affects primarily metabolic organs, such as white adipose tissue (WAT), is considered as a major cause of human obesity-associated co-morbidities. However, the molecular mechanisms initiating this inflammation in WAT are poorly understood. By combining transcriptomics, ChIP-seq and modeling approaches, we studied the global early and late responses to a high-fat diet (HFD) in visceral (vWAT) and subcutaneous (scWAT) AT, the first being more prone to obesity-induced inflammation. HFD rapidly triggers proliferation of adipocyte precursors within vWAT. However, concomitant antiadipogenic signals limit vWAT hyperplastic expansion by interfering with the differentiation of proliferating adipocyte precursors. Conversely, in scWAT, residing beige adipocytes lose their oxidizing properties and allow storage of excessive fatty acids. This phase is followed by tissue hyperplastic growth and increased angiogenic signals, which further enable scWAT expansion without generating inflammation. Our data indicate that scWAT and vWAT differential ability to modulate adipocyte number and differentiation in response to obesogenic stimuli has a crucial impact on the different susceptibility to obesity-related inflammation of these adipose tissue depots.

Indexed as

AdipogenesisCell DifferentiationAdipose Tissue, WhiteAnimalsDiet, High-FatFatty Acid-Binding ProteinsGene Expression RegulationInflammationInterleukin-1betaIntra-Abdominal FatLipid MetabolismMaleMiceMice, Inbred C57BLObesitySignal TransductionFabp4 protein, mouseFatty Acid-Binding ProteinsInterleukin-1betaTumor Necrosis Factor-alphaWnt10b protein, mouseWnt ProteinsAdipocyte precursorsAdipogenesisAdipose tissueAngiogenesisEpigeneticsGenome-scale metabolic networkMetaflammationSystem biologyTranscriptomics

Identifiers

PMID32157317
PMCPMC7867564

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.