ArticleBritish journal of cancer2020
An integrated analysis of lymphocytic reaction, tumour molecular characteristics and patient survival in colorectal cancer.
Article in British journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Predictive Role of Circulating Tumor DNA in Stage III Colon Cancer Treated With Celecoxib: A Post Hoc Analysis of the CALGB (Alliance)/SWOG 80702 Phase 3 Randomized Clinical Trial.JAMA oncology · 2026Trial
- Lymphocytic Reaction Combined with MRI Deep Learning Radiomics in Risk Stratification of Distant Metastases in Rectal Cancer.Cancers · 2026Article
- Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights.The Journal of pathology · 2026Article
- Tumor Vascular Features and Colorectal Cancer-Specific Mortality.JAMA network open · 2026Article
- Histopathologic clues to mismatch repair deficiency in colon adenocarcinoma: the role of mucinous component and intratumoral/Crohn-like immune response.BMC gastroenterology · 2026Article
- Long-term yogurt intake and colorectal cancer incidence subclassified byGut microbes · 2025Article
- Multidimensional differences of right- and left-sided colorectal cancer and their impact on targeted therapies.NPJ precision oncology · 2025Review
- Tumor-immune partitioning and clustering algorithm for identifying tumor-immune cell spatial interaction signatures within the tumor microenvironment.PLoS computational biology · 2025Article
- Article
- Germline genetic regulation of the colorectal tumor immune microenvironment.BMC genomics · 2024Article
- Immune Microenvironment in Sporadic Early-Onset versus Average-Onset Colorectal Cancer.Cancers · 2023Article
- New Histoprognostic Factors to Consider for the Staging of Colon Cancers: Tumor Deposits, Invasive Tumor Infiltration and High-Grade Budding.International journal of molecular sciences · 2023Article
- Prognostic role of inflammatory diets in colorectal cancer overall and in strata of tumor-infiltrating lymphocyte levels.Clinical and translational medicine · 2022Article
- Machine Learning Model for Predicting Postoperative Survival of Patients with Colorectal Cancer.Cancer research and treatment · 2022Article
- Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer.Cancer immunology, immunotherapy : CII · 2022Article
- Spatial Organization and Prognostic Significance of NK and NKT-like Cells via Multimarker Analysis of the Colorectal Cancer Microenvironment.Cancer immunology research · 2022Article
- Smoking and Incidence of Colorectal Cancer Subclassified by Tumor-Associated Macrophage Infiltrates.Journal of the National Cancer Institute · 2022Article
- Coffee Intake of Colorectal Cancer Patients and Prognosis According to Histopathologic Lymphocytic Reaction and T-Cell Infiltrates.Mayo Clinic proceedings · 2022Article
- Desmoplastic Reaction, Immune Cell Response, and Prognosis in Colorectal Cancer.Frontiers in immunology · 2022Article
- Relationship between Fusobacterium nucleatum and antitumor immunity in colorectal cancer liver metastasis.Cancer science · 2021Article
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Authors and funding
26 authors.
Funding
Abstract
backgroundHistological lymphocytic reaction is regarded as an independent prognostic marker in colorectal cancer. Considering the lack of adequate statistical power, adjustment for selection bias and comprehensive tumour molecular data in most previous studies, we investigated the strengths of the prognostic associations of lymphocytic reaction in colorectal carcinoma by utilising an integrative database of two prospective cohort studies.
methodsWe examined Crohn's-like reaction, intratumoural periglandular reaction, peritumoural reaction and tumour-infiltrating lymphocytes in 1465 colorectal carcinoma cases. Using covariate data of 4420 colorectal cancer cases in total, inverse probability-weighted Cox proportional hazard regression model was used to control for selection bias (due to tissue availability) and potential confounders, including stage, MSI status, LINE-1 methylation, PTGS2 and CTNNB1 expression, KRAS, BRAF and PIK3CA mutations, and tumour neoantigen load.
resultsHigher levels of each lymphocytic reaction component were associated with better colorectal cancer-specific survival (P
conclusionsThe four lymphocytic reaction components are prognostic biomarkers in colorectal carcinoma.
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