Evidence map›Paper›PMID 32157178›Full record

ArticleScientific reports2020

Eosinophil accumulation in postnatal lung is specific to the primary septation phase of development.

Lucas F Loffredo, Mackenzie E Coden, Brian M Jeong, Matthew T Walker, Kishore Reddy Anekalla, Ton C Doan, Raul Rodriguez, Mandy Browning, Kiwon Nam, James J Lee and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

  1. The role of myeloid immune cells in lung epithelial repair.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  2. Review
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  8. The role of mTOR activation in steroid-resistant asthma: insights from particulate matter-induced mouse model and patient studies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  9. Review
  10. Eosinophils in Rheumatoid Arthritis: A Multifaceted Role in the Pathogenesis of the Disease.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2025
    Article
  11. Article
  12. Review
  13. Eosinophil Phenotypes Are Functionally Regulated by Resolvin D2 during Allergic Lung Inflammation.American journal of respiratory cell and molecular biology · 2023
    Article
  14. Emerging functions of tissue-resident eosinophils.The Journal of experimental medicine · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Lucas F LoffredoDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Mackenzie E CodenDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Brian M JeongDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Matthew T WalkerDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Kishore Reddy AnekallaDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-8366-5782
Ton C DoanDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Raul RodriguezDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Mandy BrowningDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Kiwon NamDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
James J LeeDepartment of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, USA.
Hiam Abdala-ValenciaDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Sergejs BerdnikovsDivision of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. s-berdnikovs@northwestern.edu.
Northwestern University · USMayo Clinic in Arizona · US

Funding

Hormones in allergic diseaseR01AI127783 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BERDNIKOVS, SERGEJS · 2017 to 2021
$2.0M
Novel asthma pathogenesis genes in the mucosa of the human airwaysR21AI115055 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BERDNIKOVS, SERGEJS · 2015 to 2016
$425k
NIAID NIH HHS R01 AI127783NIAID NIH HHS R21 AI115055
6 · The paper itself

Abstract

Type 2 immune cells and eosinophils are transiently present in the lung tissue not only in pathology (allergic disease, parasite expulsion) but also during normal postnatal development. However, the lung developmental processes underlying airway recruitment of eosinophils after birth remain unexplored. We determined that in mice, mature eosinophils are transiently recruited to the lung during postnatal days 3-14, which specifically corresponds to the primary septation/alveolarization phase of lung development. Developmental eosinophils peaked during P10-14 and exhibited Siglec-F

Indexed as

Gene Expression RegulationAnimalsEosinophilsExtracellular MatrixGene Expression ProfilingLungMesodermMiceMice, Inbred C57BLMice, Knockout

Identifiers

PMID32157178
PMCPMC7064572
OpenAlexW3012322158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.