ArticleJournal of human hypertension2021
Independent and combined effects of triglyceride-glucose index on prehypertension risk: a cross-sectional survey in China.
Article in Journal of human hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Childhood triglyceride-glucose index and pre-hypertension in adulthood: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Elevated triglyceride-glucose index is a risk factor for progression to prehypertension in normoglycemic Japanese: a 5-year retrospective cohort study.Clinical hypertension · 2024Article
- Central and peripheral blood pressures in relation to the triglyceride-glucose index in a Chinese population.Cardiovascular diabetology · 2024Article
- Dose-response association between dietary folate and niacin intakes with diabetes among Chinese adults: a cross-sectional study.Journal of health, population, and nutrition · 2023Article
- Association between triglyceride glucose index and peak growth hormone in children with short stature.Scientific reports · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Triglyceride-glucose (TyG) index is considered a simple and feasible indicator of insulin resistance (IR). This study aims to delve into the association and interaction of TyG index on the risk of prehypertension in Chinese adults. A community based cross-sectional survey conducted in Chinese population. Eligible participants were recruited, and questionnaire survey, anthropometric tests, and blood samples collection were performed. TyG index was obtained as ln [fasting TG(mg/dl) × FPG(mg/dl)/2]. Logistic regression model and the area under the receiver-operating characteristics (ROC) curves (AUC) were analyzed. Interaction analysis was conducted by calculating relative excess risk for interaction (RERI), attributable proportion for interaction (AP) as well as synergy index (SI). A total of 3115 recruited participants (1307 males and 1808 females) were aged 60.82 years on average. The prevalence of prehypertension reached 36.4% on the whole, 37.6% in male and 35.5% in female, respectively. The results of multivariable logistic regression model suggested that the adjusted OR for prehypertension was upregulated across TyG index quartiles, up to 2.06 (95% CI:1.53-2.77) for quartiles 4 versus quartiles 1. Furthermore, TyG index outperformed FPG (Z = 2.15, p = 0.032) and TG (Z = 6.10, p < 0.001) in discriminating prehypertension risk. Besides, TyG index with abdominal obesity (RERI:1.53, 95% CI:0.39-2.67; AP: 0.37, 95% CI: 0.16-0.59; SI:1.96, 95% CI:1.15-3.34) displayed a noticeable interaction on risk of prehypertension. Our study indicated that a higher TyG index rose the risk of prehypertension independently and synergistically with abdominal obesity in Chinese adults. Furthermore, it exhibited a higher predictability compared with conventional indices.
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