ArticleScientific reports2020
Altered directed functional connectivity of the right amygdala in depression: high-density EEG study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Deep Brain Stimulation of the Habenula: Systematic Review of the Literature and Clinical Trial Registries.Frontiers in psychiatry · 2021Pooled it
- Association of hippocampus, entorhinal cortex, and amygdala with thyroid function: a bilateral volumetric analysis.Thyroid research · 2026Article
- Are neurasthenia and depression the same disease entity? An electroencephalography study.BMC psychiatry · 2025Article
- Resting-state functional magnetic resonance imaging and support vector machines for the diagnosis of major depressive disorder in adolescents.World journal of psychiatry · 2024Review
- Functional Network Connectivity for Components of Depression-Related Psychological Fragility.Brain sciences · 2024Article
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- The right amygdala and migraine: Analyzing volume reduction and its relationship with symptom severity.PloS one · 2024Article
- Clinical Improvement in Depression and Cognitive Deficit Following Electroconvulsive Therapy.Diagnostics (Basel, Switzerland) · 2023Review
- Prefrontal network engagement by deep brain stimulation in limbic hubs.Frontiers in human neuroscience · 2023Article
- From pulse width modulated TENS to cortical modulation: based on EEG functional connectivity analysis.Frontiers in neuroscience · 2023Article
- Phase-Amplitude Coupling and Phase Synchronization Between Medial Temporal, Frontal and Posterior Brain Regions Support Episodic Autobiographical Memory Recall.Brain topography · 2022Article
- Prefrontal Lobe and Posterior Cingulate Cortex Activations in Patients with Major Depressive Disorder by Using Standardized Weighted Low-Resolution Electromagnetic Tomography.Journal of personalized medicine · 2021Article
- Investigating the spectral features of the brain meso-scale structure at rest.Human brain mapping · 2021Article
- Reduced Effective Connectivity in the Motor Cortex in Parkinson's Disease.Brain sciences · 2021Article
- Experimental Protocol to Assess Neuromuscular Plasticity Induced by an Exoskeleton Training Session.Methods and protocols · 2021Article
- Cortical correlates in upright dynamic and static balance in the elderly.Scientific reports · 2021Article
- Association of Midlife Depressive Symptoms with Regional Amyloid-β and Tau in the Framingham Heart Study.Journal of Alzheimer's disease : JAD · 2021Article
- Face Recognition Brain Functional Connectivity in Patients With Major Depression: A Brain Source Localization Study by ERP.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cortico-striatal-pallidal-thalamic and limbic circuits are suggested to play a crucial role in the pathophysiology of depression. Stimulation of deep brain targets might improve symptoms in treatment-resistant depression. However, a better understanding of connectivity properties of deep brain structures potentially implicated in deep brain stimulation (DBS) treatment is needed. Using high-density EEG, we explored the directed functional connectivity at rest in 25 healthy subjects and 26 patients with moderate to severe depression within the bipolar affective disorder, depressive episode, and recurrent depressive disorder. We computed the Partial Directed Coherence on the source EEG signals focusing on the amygdala, anterior cingulate, putamen, pallidum, caudate, and thalamus. The global efficiency for the whole brain and the local efficiency, clustering coefficient, outflow, and strength for the selected structures were calculated. In the right amygdala, all the network metrics were significantly higher (p < 0.001) in patients than in controls. The global efficiency was significantly higher (p < 0.05) in patients than in controls, showed no correlation with status of depression, but decreased with increasing medication intake ([Formula: see text]). The amygdala seems to play an important role in neurobiology of depression. Practical treatment studies would be necessary to assess the amygdala as a potential future DBS target for treating depression.
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