Trial reportScientific reports2020
Acute increases in brain-derived neurotrophic factor in plasma following physical exercise relates to subsequent learning in older adults.
Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Priming Effects of Aerobic Exercise on Cognitive Training of Patients With Ischemic and Hemorrhagic Stroke
Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Pooled it
- The effect of physical exercise on circulating brain-derived neurotrophic factor in healthy subjects: A meta-analysis of randomized controlled trials.Brain and behavior · 2022Pooled it
- The Effects of Combined Cognitive-Physical Interventions on Cognitive Functioning in Healthy Older Adults: A Systematic Review and Multilevel Meta-Analysis.Frontiers in human neuroscience · 2022Pooled it
- Effects of dance mindfulness and combined interventions on social anxiety in left behind rural adolescents: a randomized controlled trial.Scientific reports · 2026Trial
- Lactate Threshold Training Program on Patients with Multiple Sclerosis: A Multidisciplinary Approach.Nutrients · 2021Trial
- Higher VOScientific reports · 2021Trial
- Distinct association of plasma BDNF concentration and cognitive function in depressed patients treated with vortioxetine or escitalopram.Psychopharmacology · 2021Trial
- Acute Skeletal Muscle Activation Through Physical Exercise and Its Effects on Cognitive Performance and Neurobiological Markers in Adults: A Scoping Review.Muscles (Basel, Switzerland) · 2026Review
- Effects of mindful awareness intervention folk-dance intervention and combined intervention on academic burnout in left-behind children in rural China.Frontiers in psychology · 2026Article
- Integrated effects of a 12-week intermittent combined exercise on cognitive function, physical performance, and neurophysiological biomarkers in older women.Journal of exercise rehabilitation · 2025Article
- Matched Metabolic Stress Preserves Myokine Responses Regardless of Mechanical Load: A Randomized, Controlled Crossover Trial.Metabolites · 2025Article
- Mechanisms of interventions targeting modifiable factors for dementia risk reduction.Molecular neurodegeneration · 2025Review
- Acute effects of a single bout of high-intensity strength and endurance exercise on cognitive biomarkers in young adults and elderly men: a within-subjects crossover study.Journal of translational medicine · 2025Article
- Proposed Mechanism of Action for Three Music-Based Interventions for Behavioral and Psychologic Symptoms of Dementia.Music therapy perspectives · 2025Article
- The impact of badminton participation on attention control in college students: the mediating role of flow experience.Frontiers in psychology · 2025Article
- Effects of a pain oriented biobehavioral therapeutic education program on brain plasticity and pain intensity in subjects with chronic musculoskeletal pain: a feasibility study of a randomized controlled trial.Frontiers in neuroscience · 2025Article
- The interactions between energy homeostasis and neurovascular plasticity.Nature reviews. Endocrinology · 2024Review
- Greater physical fitness (Acta physiologica (Oxford, England) · 2024Article
- Pro-Brain-Derived Neurotrophic Factor (BDNF), but Not Mature BDNF, Is Expressed in Human Skeletal Muscle: Implications for Exercise-Induced Neuroplasticity.Function (Oxford, England) · 2024Article
- Virtual realities, real recoveries: exploring the efficacy of 3MDR therapy for treatment-resistant PTSD.Frontiers in psychology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multidomain lifestyle interventions represents a promising strategy to counteract cognitive decline in older age. Brain-derived neurotrophic factor (BDNF) is essential for experience-dependent plasticity and increases following physical exercise, suggesting that physical exercise may facilitate subsequent learning. In a randomized-controlled trial, healthy older adults (65-75 years) completed a 12-week behavioral intervention that involved either physical exercise immediately before cognitive training (n = 25; 13 females), physical exercise immediately after cognitive training (n = 24; 11 females), physical exercise only (n = 27; 15 females), or cognitive training only (n = 21; 12 females). We hypothesized that cognition would benefit more from cognitive training when preceded as opposed to followed by physical exercise and that the relationship between exercise-induced increases in peripheral BDNF and cognitive training outcome would be greater when cognitive training is preceded by physical exercise. Greater increases of plasma BDNF were associated with greater cognitive training gains on trained task paradigms, but only when such increases preceded cognitive training (ß = 0.14, 95% CI [0.04, 0.25]). Average cognitive training outcome did not differ depending on intervention order (ß = 0.05, 95% CI [-0.10, 0.20]). The study provides the first empirical support for a time-critical but advantageous role for post-exercise increases in peripheral BDNF for learning at an interindividual level in older adults, with implications for future multidomain lifestyle interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.