ArticleAging2020
Development, validation and clinical impact of a prediction model for 6-month mortality in older cancer patients: the GRADE.
Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Using the Geriatric Core Dataset (G-CODE) to predict mortality in older patients with cancer: development and external validation.British journal of cancer · 2026Article
- CT-Based Body Composition and Frailty as Predictors of Survival Among Older Adults With Gastrointestinal Malignancies.Journal of cachexia, sarcopenia and muscle · 2025Article
- Comparison of the prognostic value of eight nutrition-related tools in older patients with cancer: A prospective study.The journal of nutrition, health & aging · 2024Article
- Predicting Risk of Severe Toxicity and Early Death in Older Adult Patients Treated with Chemotherapy.Cancers · 2023Article
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- Gait speed as a predictor of mortality in older men with cancer: A longitudinal study in Peru.Heliyon · 2022Article
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- The Pre-Operative GRADE Score Is Associated with 5-Year Survival among Older Patients with Cancer Undergoing Surgery.Cancers · 2021Article
- Prognostic Value of Prospective Longitudinal CRP to Albumin Ratio among Older Outpatients with Cancer.Cancers · 2021Article
- Management of Metastatic Colorectal Carcinoma in Older Adults: Balancing Risks and Benefits of Novel Therapies.Drugs & aging · 2021Review
- Development and Validation of an Early Mortality Risk Score for Older Patients Treated with Chemotherapy for Cancer.Journal of clinical medicine · 2021Article
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Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo develop, validate, and assess the clinical impact of a clinical score to predict a 6-month mortality risk among older cancer patients.
resultsThe mean age was 81.2 ± 6.1 years (women: 54%, various cancers, metastatic cancer: 45%). The score, namely the GRADE, included two geriatric variables (unintentional weight loss, impaired mobility), two oncological variables (cancer site, cancer extension), and exclusively supportive care. Up to a 14% risk of early death, the decision curves suggest that cancer treatment should be instated.
conclusionWe have developed and validated a simple score, easy to implement in daily oncological practice, to predict early death among older cancer patients which could guide oncologists in their treatment decisions.
methods603 outpatients prospectively included in the Physical Frailty in Elderly Cancer patients cohort study. We created a multivariate prediction model by evaluating the strength of the individual components of the Geriatric Assessment regarding risk of death at 6 months. Each component was evaluated by univariate analysis and the significant variables (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.