Evidence map›Paper›PMID 32156825›Full record

ArticlemBio2020

The Absence of (p)ppGpp Renders Initiation of Escherichia coli Chromosomal DNA Synthesis Independent of Growth Rates.

Llorenç Fernández-Coll, Monika Maciag-Dorszynska, Krishma Tailor, Stephen Vadia, Petra Anne Levin, Agnieszka Szalewska-Palasz, Michael Cashel

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 64 citations in OpenAlex.

  1. Review
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  3. Article
  4. Article
  5. Article
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  7. Article
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  9. Review
  10. TheJournal of bacteriology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. (p)ppGpp is required for virulence ofInfection and immunity · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Llorenç Fernández-CollIntramural Research Program, Eunice Kennedy Shriver NICHD, NIH, Bethesda, Maryland, USA.
Monika Maciag-DorszynskaDepartment of Bacterial Molecular Genetics, University of Gdansk, Gdansk, Poland.
Krishma TailorIntramural Research Program, Eunice Kennedy Shriver NICHD, NIH, Bethesda, Maryland, USA.
Stephen VadiaDepartment of Biology, Washington University in St. Louis, Saint Louis, Missouri, USA.
Petra Anne LevinDepartment of Biology, Washington University in St. Louis, Saint Louis, Missouri, USA.
Agnieszka Szalewska-PalaszDepartment of Bacterial Molecular Genetics, University of Gdansk, Gdansk, Poland.
Michael CashelIntramural Research Program, Eunice Kennedy Shriver NICHD, NIH, Bethesda, Maryland, USA cashelm@mail.nih.gov.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of Gdańsk · PLWashington University in St. Louis · US

Funding

Integration Of Macromolecular SynthesisZIAHD000067 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI CASHEL, MICHAEL · 2009 to 2021
$6.1M
HOMEOSTATIC CONTROL OF BACTERIAL GROWTH AND CELL DIVISIONR35GM127331 · NIGMS · WASHINGTON UNIVERSITY · PI Petra Anne Levin · 2018 to 2026
$4.3M
NIGMS NIH HHS R35 GM127331
6 · The paper itself

Abstract

The initiation of

Indexed as

DNA ReplicationBacterial ProteinsChromosomes, BacterialDNA, BacterialDNA-Binding ProteinsDNA GyraseEscherichia coliGuanosine PentaphosphateProtein BiosynthesisBacterial ProteinsDnaA protein, BacteriaDNA, BacterialDNA-Binding ProteinsDNA GyraseGuanosine Pentaphosphatechromosome initiationDNA replicationEscherichia coligrowth rateppGpp

Identifiers

PMID32156825
PMCPMC7064777
OpenAlexW3011817280

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.