Evidence map›Paper›PMID 32156820›Full record

ArticlemBio2020

A Shift in Central Metabolism Accompanies Virulence Activation in Pseudomonas aeruginosa.

Kumar Perinbam, Jenu V Chacko, Anerudh Kannan, Michelle A Digman, Albert Siryaporn

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 53 citations in OpenAlex.

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  9. Label-free metabolic imaging ofFrontiers in cellular and infection microbiology · 2025
    Article
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  12. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kumar Perinbam *Department of Physics and Astronomy, University of California, Irvine, Irvine, California, USA.
Jenu V Chacko *Department of Biomedical Engineering, University of California, Irvine, Irvine, California, USA.
Anerudh KannanDepartment of Physics and Astronomy, University of California, Irvine, Irvine, California, USA.
Michelle A DigmanDepartment of Biomedical Engineering, University of California, Irvine, Irvine, California, USA.
Albert SiryapornDepartment of Physics and Astronomy, University of California, Irvine, Irvine, California, USA asirya@uci.edu.
University of California, Irvine · US

Funding

Uncover Strategies Used By Biological SystemsP50GM076516 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LANDER, ARTHUR D · 2007 to 2016
$25.1M
TRD4: Phasor analysisP41GM103540 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GRATTON, ENRICO · 2012 to 2020
$12.5M
Real-time metabolic analysis of virulence activation in P. aeruginosa using fluorescence lifetime imaging microscopy (FLIM)R21AI139968 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SIRYAPORN, ALBERT · 2019 to 2020
$382k
Role of mechanosensation in P. aeruginosa virulence and colonizationK22AI112816 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SIRYAPORN, ALBERT · 2016 to 2017
$265k
NIAID NIH HHS K22 AI112816NIAID NIH HHS R21 AI139968NIGMS NIH HHS P41 GM103540NIGMS NIH HHS P50 GM076516
6 · The paper itself

Abstract

The availability of energy has significant impact on cell physiology. However, the role of cellular metabolism in bacterial pathogenesis is not understood. We investigated the dynamics of central metabolism during virulence induction by surface sensing and quorum sensing in early-stage biofilms of the multidrug-resistant bacterium

Indexed as

BiofilmsMicroscopy, FluorescenceNADPseudomonas aeruginosaQuorum SensingVirulenceNADantivirulencecentral metabolismFLIMfluorescence lifetime imaging microscopyPilY1quorum sensingsurface sensingvirulence regulation

Identifiers

PMID32156820
PMCPMC7064766
OpenAlexW3011278318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.