Evidence map›Paper›PMID 32156806›Full record

ArticlemBio2020

New Host-Directed Therapeutics for the Treatment of Clostridioides difficile Infection.

Jourdan A Andersson, Alex G Peniche, Cristi L Galindo, Prapaporn Boonma, Jian Sha, Ruth Ann Luna, Tor C Savidge, Ashok K Chopra, Sara M Dann

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Mechanisms ofFrontiers in cellular and infection microbiology · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Expert opinion on therapeutic targets · 2021
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Jourdan A AnderssonDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Alex G PenicheDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Cristi L GalindoDepartment of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Prapaporn BoonmaFaculty of Medicine, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.
Jian ShaDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Ruth Ann LunaDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
Tor C SavidgeDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
Ashok K ChopraDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA achopra@utmb.edu smdann@utmb.edu.
Sara M DannDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA achopra@utmb.edu smdann@utmb.edu.
The University of Texas Medical Branch at Galveston · USTexas Children's Hospital · USBaylor College of Medicine · USKing Mongkut's Institute of Technology Ladkrabang · THRutgers New Jersey Medical School

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
Decoding Antibiotic-induced Susceptibility to Clostridium difficile InfectionU01AI124290 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BRITTON, ROBERT A, GAREY, KEVIN W · 2016 to 2020
$7.9M
Texas Medical Center Training Program in Antimicrobial ResistanceT32AI141349 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GARSIN, DANIELLE A · 2019 to 2023
$1.3M
FDA approved non-antibiotic drugs to combat multiple drug resistant microbesR56AI132682 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CHOPRA, ASHOK K, DANN, SARA M · 2018 to 2018
$583k
NIAID NIH HHS R56 AI132682NIAID NIH HHS T32 AI141349NIAID NIH HHS U01 AI124290NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

Frequent and excessive use of antibiotics primes patients to

Indexed as

Immunity, InnateAmoxapineAnimalsClostridioides difficileClostridium InfectionsDoxapramDrug RepositioningFemaleImmunomodulationMaleMiceMice, Inbred C57BLMicrobiotaRNA-SeqSpecific Pathogen-Free OrganismsTrifluoperazineAmoxapineDoxapramTrifluoperazineClostridioides difficilegermfree micehost-directed therapeuticsmechanism of actionmicrobiotamouse model of infection

Identifiers

PMID32156806
PMCPMC7064747
OpenAlexW3012029590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.