Evidence map›Paper›PMID 32156789›Full record

ArticleRespiratory care2020

Unanticipated Respiratory Compromise and Unplanned Intubations on General Medical and Surgical Floors.

Armando D Bedoya, Nrupen A Bhavsar, Bhargav Adagarla, Courtney B Page, Benjamin A Goldstein, Neil R MacIntyre

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Respiratory care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Armando D BedoyaDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, North Carolina.
Nrupen A BhavsarDivision of General Internal Medicine, Department of Medicine, Duke University.
Bhargav AdagarlaDuke Clinical Research Institute.
Courtney B PageDuke Clinical Research Institute.
Benjamin A GoldsteinDuke Clinical Research Institute.
Neil R MacIntyreDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University, Durham, North Carolina.
Duke University · USClinical Research Institute · US

Funding

Addressing Bias from Missing Data in EHR Based Studies of CVDK01HL140146 · NHLBI · DUKE UNIVERSITY · PI BHAVSAR, NRUPEN · 2018 to 2022
$829k
Understanding and predicting cardiac events in HD using real-time EHRsK25DK097279 · NIDDK · STANFORD UNIVERSITY · PI GOLDSTEIN, BENJAMIN ALAN · 2013 to 2017
$797k
NHLBI NIH HHS K01 HL140146NIDDK NIH HHS K25 DK097279
6 · The paper itself

Abstract

backgroundUnanticipated respiratory compromise that lead to unplanned intubations is a known phenomenon in hospitalized patients. Most events occur in patients at high risk in well-monitored units; less is known about the incidence, risk factors, and trajectory of patients thought at low risk on lightly monitored general care wards. The aims of our study were to quantify demographic and clinical characteristics associated with unplanned intubations on general care floors and to analyze the medications administered, monitoring strategies, and vital-sign trajectories before the event.

methodsWe performed a multicenter retrospective cohort study of hospitalized subjects on the general floor who had unanticipated, unplanned intubations on general care floors from August 2014 to February 2018.

resultsWe identified 448 unplanned intubations. The incidence rate was 0.420 per 1,000 bed-days (95% CI 0.374-0.470) in the academic hospital and was 0.430 (95% CI 0.352-0.520) and 0.394 per 1,000 bed-days (95% CI 0.301-0.506) at our community hospitals. Extrapolating these rates to total hospital admissions in the United States, we estimate 64,000 events annually. The mortality rate was 49.1%. Within 12 h preceding the event, 35.3% of the subjects received opiates. All received vital-sign assessments. Most were monitored with pulse oximetry. In contrast, 2.5% were on cardiac telemetry, and only 4 subjects used capnography; 53.7% showed significant vital-sign changes in the 24 h before the event. However, 46.3% had no significant change in any vital signs.

conclusionsOur study showed unanticipated respiratory compromise that required an unplanned intubation of subjects on the general care floor, although not common, carried a high mortality. Besides pulse oximetry and routine vital-sign assessments, very little monitoring was in use. A significant portion of the subjects had no vital-sign abnormalities leading up to the event. Further research is needed to determine the phenotype of the different etiologies of unexpected acute respiratory failure to identify better risk stratification and monitoring strategies.

Indexed as

Intubation, IntratrachealCapnographyHumansMonitoring, PhysiologicOximetryRetrospective StudiesUnited Statesairway managementepidemiologyintubationlung monitoringrespiratory insufficiency

Identifiers

PMID32156789
PMCPMC7906607
OpenAlexW3011036046

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.