Evidence map›Paper›PMID 32156785›Full record

ArticleMolecular cancer therapeutics2020

Elucidation of Pelareorep Pharmacodynamics in A Phase I Trial in Patients with

Sanjay Goel, Allyson J Ocean, Ruwan Y Parakrama, Mohammad H Ghalib, Imran Chaudhary, Umang Shah, Sengottuvel Viswanathan, Himanshu Kharkwal, Matthew Coffey, Radhashree Maitra

Open access · bronzeAbstract readClinical Trial, Phase I
In one paragraph

Article in Molecular cancer therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
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  7. Review
  8. Immunotherapy in Gastrointestinal Cancers: Current Insights.Clinical pharmacology : advances and applications · 2025
    Review
  9. Review
  10. Review
  11. Noncoding RNA Profile in Reovirus TreatedDiseases (Basel, Switzerland) · 2023
    Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Oncolytic Reovirus (pelareorep) Induces Autophagy in KRAS-mutated Colorectal Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  19. Multimodal immune activation abilities and characteristics of reovirus.American journal of translational research · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sanjay GoelDepartment of Medical Oncology, Montefiore Medical Center, Bronx, New York. sgoel@montefiore.org.ORCID 0000-0002-2798-7568
Allyson J OceanDepartment of Medical Oncology, New York-Presbyterian/Weill Cornell Medical Center, New York, New York.
Ruwan Y ParakramaDepartment of Medical Oncology, Montefiore Medical Center, Bronx, New York.
Mohammad H GhalibDepartment of Medical Oncology, Montefiore Medical Center, Bronx, New York.
Imran ChaudharyDepartment of Medical Oncology, Montefiore Medical Center, Bronx, New York.ORCID 0000-0003-0234-1602
Umang ShahDepartment of Medical Oncology, Montefiore Medical Center, Bronx, New York.
Sengottuvel ViswanathanDepartment of Medical Oncology, Montefiore Medical Center, Bronx, New York.
Himanshu KharkwalDepartment of Medical Oncology, Montefiore Medical Center, Bronx, New York.
Matthew CoffeyOncolytics Inc., Calgary, Alberta, Canada.
Radhashree MaitraDepartment of Medical Oncology, Montefiore Medical Center, Bronx, New York.ORCID 0000-0002-5365-5890
Montefiore Medical Center · USAlbert Einstein College of Medicine · USATCO (Canada) · CANewYork–Presbyterian Hospital · US

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2M
COMPARATIVE EFFECTIVENESS OF BIOLOGIC AGENTS IN ETHNIC MINORITIES WITH COLORECTAL CANCERR21AG058027 · NIA · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI GOEL, SANJAY, NEGASSA, ABDISSA · 2018 to 2019
$397k
NCI NIH HHS P30 CA013330NIA NIH HHS R21 AG058027
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MutationAdultAgedAnimalsAntineoplastic Combined Chemotherapy ProtocolsApoptosisBevacizumabBiomarkers, TumorCell ProliferationColorectal NeoplasmsCombined Modality TherapyFemaleHumansIrinotecanMaleMaximum Tolerated DoseBevacizumabBiomarkers, TumorIrinotecanKRAS protein, humanProto-Oncogene Proteins p21(ras)reolysin

Identifiers

PMID32156785
PMCPMC7207225
OpenAlexW3012106145

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.