Evidence map›Paper›PMID 32156757›Full record

ArticleDevelopment (Cambridge, England)2020

A dorsal-ventral gradient of Wnt3a/β-catenin signals controls mouse hindgut extension and colon formation.

Robert J Garriock, Ravindra B Chalamalasetty, JianJian Zhu, Mark W Kennedy, Amit Kumar, Susan Mackem, Terry P Yamaguchi

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  10. Intestinal Wnt in the transition from physiology to oncology.World journal of clinical oncology · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Robert J GarriockCenter for Cancer Research, Cancer and Developmental Biology Laboratory, Cell Signaling in Vertebrate Development Section, NCI-Frederick, NIH, Frederick, MD 21702, USA.ORCID 0000-0002-4704-1526
Ravindra B ChalamalasettyCenter for Cancer Research, Cancer and Developmental Biology Laboratory, Cell Signaling in Vertebrate Development Section, NCI-Frederick, NIH, Frederick, MD 21702, USA.
JianJian ZhuCenter for Cancer Research, Cancer and Developmental Biology Laboratory, Cell Signaling in Vertebrate Development Section, NCI-Frederick, NIH, Frederick, MD 21702, USA.
Mark W KennedyCenter for Cancer Research, Cancer and Developmental Biology Laboratory, Cell Signaling in Vertebrate Development Section, NCI-Frederick, NIH, Frederick, MD 21702, USA.
Amit KumarCenter for Cancer Research, Cancer and Developmental Biology Laboratory, Cell Signaling in Vertebrate Development Section, NCI-Frederick, NIH, Frederick, MD 21702, USA.
Susan MackemCenter for Cancer Research, Cancer and Developmental Biology Laboratory, Cell Signaling in Vertebrate Development Section, NCI-Frederick, NIH, Frederick, MD 21702, USA.ORCID 0000-0002-9095-9914
Terry P YamaguchiCenter for Cancer Research, Cancer and Developmental Biology Laboratory, Cell Signaling in Vertebrate Development Section, NCI-Frederick, NIH, Frederick, MD 21702, USA yamagute@mail.nih.gov.ORCID 0000-0002-7452-4419
Center for Cancer Research · US

Funding

The Role of Wnt Genes in Vertebrate Development and CancerZIABC010345 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YAMAGUCHI, TERENCE · 2009 to 2025
$23.3M
6 · The paper itself

Abstract

Despite the importance of Wnt signaling for adult intestinal stem cell homeostasis and colorectal cancer, relatively little is known about its role in colon formation during embryogenesis. The development of the colon starts with the formation and extension of the hindgut. We show that

Indexed as

Body PatterningWnt Signaling PathwayAnimalsbeta CateninBone Morphogenetic ProteinsCell ProliferationColonEmbryo, MammalianGene Expression Regulation, DevelopmentalMice, TransgenicMorphogenesisWnt3A Proteinbeta CateninBone Morphogenetic ProteinsWnt3A ProteinColonEndodermHindgutIntestineMouseWnt3aβ-Catenin

Identifiers

PMID32156757
PMCPMC7174843
OpenAlexW3010754212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.