ReviewClinical cancer research : an official journal of the American Association for Cancer Research2020
Small-Cell Carcinoma of the Ovary, Hypercalcemic Type-Genetics, New Treatment Targets, and Current Management Guidelines.
Open access · bronzeAbstract readReview
In one paragraph
Review in Clinical cancer research : an official journal of the American Association for Cancer Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it, 165 citations in OpenAlex.
- Clinical characteristics and status of treatment of small-cell carcinoma of the ovary, hypercalcemic type in the Chinese population: a meta-analysis.Journal of gynecologic oncology · 2024Pooled it
- Tazemetostat, an EZH2 inhibitor, in solid tumors harboring SWI/SNF alterations: a phase II basket study.Nature communications · 2026Trial
- A phase II basket trial of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART) SWOG S1609: durable responses and delayed pseudoprogression in small cell carcinoma of the ovary, hypercalcemic type cohort.Cancer communications (London, England) · 2025Trial
- Surgical Management of Solid Tumors With Hematologic Manifestations: A Mechanism-Based Clinical Review.European journal of haematology · 2026Review
- Article
- Pregnancy-Associated Small Cell Carcinoma of the Ovary, Hypercalcaemic Type Initially Misdiagnosed as Granulosa Cell Tumour: Diagnostic Pitfalls, Treatment Challenges, and Molecular Confirmation by Next-Generation Sequencing.Cancer reports (Hoboken, N.J.) · 2026Article
- When Immunophenotype Is Not Identity: A Clinicopathological Review of Neuroendocrine Differentiation in Tumors of the Female Genital Tract.Diagnostics (Basel, Switzerland) · 2026Review
- European Reference Networks - a flagship activity of the EU in the field of rare and complex diseases: from 2017 to 2025.Orphanet journal of rare diseases · 2026Review
- Clinicopathological and molecular characteristics of small cell carcinoma of the ovary, hypercalcemic type: three case reports.Discover oncology · 2026Article
- A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform.Science (New York, N.Y.) · 2026Article
- Synthetic lethality between RB-loss and E2F3 inhibition in small cell cancers targeted by pyrimidine synthesis blockade.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- CT imaging characteristics of ovarian small cell carcinoma: correlation with clinicopathology and prognosis.BMC medical imaging · 2026Article
- SMARCA4/2 loss reduces BCL-xL expression and confers a druggable MCL1 dependency in cancer.NPJ precision oncology · 2026Article
- Long-term remission after multimodal therapy in metastatic small cell carcinoma of the ovary, hypercalcemic type: A case report.Gynecologic oncology reports · 2026Article
- Clinicopathologic features of SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma: A case report and review of literature.World journal of gastrointestinal oncology · 2026Article
- Small cell carcinoma of the ovary, hypercalcemic type complicated by enterocutaneous fistula: a case report.Journal of medical case reports · 2025Article
- Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): About three case reports.Gynecologic oncology reports · 2025Article
- Article
- BRG1 Loss Is Frequent in Lung Cancer and Transforms Lung Epithelial Cells via Transcriptional and Epigenetic Reprograming.Cancers · 2025Article
- New histopathological and molecular findings in gynecological cancers.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 13 institutions in 4 countries.
Marc TischkowitzDepartment of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom. mdt33@cam.ac.uk weissman@med.unc.edu.
Sidong HuangDepartment of Biochemistry, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-2838-4726
Susana BanerjeeThe Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, United Kingdom.
Jennifer HagueEast Anglian Medical Genetics Unit, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom.ORCID 0000-0002-9779-8009
William P D HendricksTranslational Genomics Research Institute, Division of Integrated Cancer Genomics, Phoenix, Arizona.ORCID 0000-0001-7192-8699
David G HuntsmanBC Cancer, Vancouver, British Columbia, Canada.
Jessica D LangTranslational Genomics Research Institute, Division of Integrated Cancer Genomics, Phoenix, Arizona.
Krystal A OrlandoDepartment of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina.
Amit M OzaPrincess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
Patricia PautierGustave Roussy, Villejuif, France.ORCID 0000-0002-1459-268X
Isabelle Ray-CoquardCentre Anti cancereux Léon Bérard, & University Claude Bernard Lyon, GINECO Group, Lyon, France.
Jeffrey M TrentTranslational Genomics Research Institute, Division of Integrated Cancer Genomics, Phoenix, Arizona.
Michael WitcherThe Lady Davis Institute of the Jewish General Hospital, Department of Oncology, McGill University, Montreal, Canada.
Leora WitkowskiDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.
W Glenn McCluggageDepartment of Pathology, Belfast Health and Social Care Trust, Belfast, United Kingdom.
Douglas A LevineGynecologic Oncology, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, New York.ORCID 0000-0003-1038-8232
William D FoulkesThe Lady Davis Institute of the Jewish General Hospital, Department of Oncology, McGill University, Montreal, Canada.ORCID 0000-0001-7427-4651
Bernard E WeissmanDepartment of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina. mdt33@cam.ac.uk weissman@med.unc.edu.ORCID 0000-0002-1827-2309
Translational Genomics Research Institute · USCambridge University Hospitals NHS Foundation Trust · GBMcGill University Health Centre · CAUniversity of North Carolina at Chapel Hill · USBC Cancer Agency · CABelfast Health and Social Care Trust · GBInstitut Gustave Roussy · FRJewish General Hospital · CAMcGill Genome Centre · CANYU Langone Health · USPrincess Margaret Cancer Centre · CARoyal Marsden NHS Foundation Trust · GBUniversité Claude Bernard Lyon 1 · FR
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MThe Tumor Suppressor Role of SMARCA4 in SCCOHTR01CA195670 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HUNTSMAN, DAVID, TRENT, JEFFREY M. · 2015 to 2019
$3.7MCharacterization of the role of super-enhancers in ovarian cancer treatment responseK99CA234391 · NCI · TRANSLATIONAL GENOMICS RESEARCH INST · PI LANG, JESSICA DIANE · 2019 to 2020
$223kCancer Research UK 27223Cancer Research UK C61296/A27223CIHR FDN- 148390CIHR MOP-130540CIHR PJT-156233NCI NIH HHS K99 CA234391NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA195670
Abstract
Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and highly aggressive ovarian malignancy. In almost all cases, it is associated with somatic and often germline pathogenic variants in
Indexed as
Antineoplastic Combined Chemotherapy ProtocolsCarcinoma, Small CellChemotherapy, AdjuvantChromatin Assembly and DisassemblyDNA HelicasesFemaleGynecologyHumansHypercalcemiaMedical OncologyMutationNuclear ProteinsOvarian NeoplasmsOvariectomyOvaryPractice Guidelines as TopicDNA HelicasesNuclear ProteinsSMARCA4 protein, humanTranscription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.