ArticleProceedings of the National Academy of Sciences of the United States of America2020
Structural and mechanistic insights into secretagogin-mediated exocytosis.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
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22 citing papers in PubMed, 34 citations in OpenAlex.
- Comparative analysis of SCGN expression patterns in the anterior pituitary gland of mouse, pig, and human by single-cell transcriptomics.Journal of neuroendocrinology · 2026Article
- Syntaxin1A in synaptopathies: From molecular mechanisms to therapeutic implications in neurological disorders (Review).Biomedical reports · 2026Review
- Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies.American journal of human genetics · 2025Article
- Secretagogin Is Highly Expressed in Enteroendocrine K Cells and Plays a Critical Role in Nutrient-Induced GIP Secretion.Journal of the Endocrine Society · 2025Article
- A hydrophobic groove in secretagogin allows for alternate interactions with SNAP-25 and syntaxin-4 in endocrine tissues.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- From interaction networks to interfaces, scanning intrinsically disordered regions using AlphaFold2.Nature communications · 2024Article
- Identification of molecular subtypes and diagnostic model in clear cell renal cell carcinoma based on collagen-related genes may predict the response of immunotherapy.Frontiers in pharmacology · 2024Article
- FAM91A1-TBC1D23 complex structure reveals human genetic variations susceptible for PCH.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Secretagogin regulates asynchronous and spontaneous glutamate release in hippocampal neurons through interaction with Doc2α.Life medicine · 2023Article
- Construction of PLGA Porous Microsphere-Based Artificial Pancreatic Islets Assisted by the Cell Centrifugation Perfusion Technique.ACS omega · 2023Article
- SCGN deficiency is a risk factor for autism spectrum disorder.Signal transduction and targeted therapy · 2023Article
- Secretagogin as a marker to distinguish between different neuron types in human frontal and temporal cortex.Frontiers in neuroanatomy · 2023Article
- ox-LDL induces autophagy-mediated apoptosis by suppressing secretagogin-regulated autophagic flux in pancreatic β-cells.Acta biochimica et biophysica Sinica · 2022Article
- Endoplasmic Reticulum in Metaplasticity: From Information Processing to Synaptic Proteostasis.Molecular neurobiology · 2022Review
- SNX27-FERM-SNX1 complex structure rationalizes divergent trafficking pathways by SNX17 and SNX27.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Model-based analysis uncovers mutations altering autophagy selectivity in human cancer.Nature communications · 2021Article
- GMPPB-congenital disorders of glycosylation associate with decreased enzymatic activity of GMPPB.Molecular biomedicine · 2021Article
- Cryo-EM structures of human GMPPA-GMPPB complex reveal how cells maintain GDP-mannose homeostasis.Nature structural & molecular biology · 2021Article
- Phosphorylation of SNX27 by MAPK11/14 links cellular stress-signaling pathways with endocytic recycling.The Journal of cell biology · 2021Article
- Onecut Regulates Core Components of the Molecular Machinery for Neurotransmission in Photoreceptor Differentiation.Frontiers in cell and developmental biology · 2021Article
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Authors and funding
15 authors at 2 institutions in 2 countries.
Jiao QinKey Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China.
Qi LiuKey Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China.
Zhe LiuDepartment of Pediatric Surgery and Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041 Chengdu, China.
Yun-Zu PanDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Luis Sifuentes-DominguezDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Karolina P StepienDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Yan WangKey Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China.
Yingfeng TuKey Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China.
Shuai TanKey Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China.
Yuan WangKey Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China.
Qingxiang SunKey Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China.
Xianming MoDepartment of Pediatric Surgery and Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041 Chengdu, China.
Josep RizoDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Ezra BursteinDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Da JiaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy and Collaborative Innovation Center of Biotherapy, Sichuan University, 610041 Chengdu, China; jiada@scu.edu.cn.ORCID 0000-0002-2205-1998
Sichuan University · CNThe University of Texas Southwestern Medical Center · US
Funding
Mechanisms of neurotransmitter release and its regulationR35NS097333 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2017 to 2024
$7.0MANTECEDANTS SEQUELAE OF CHILDHOOD ONSET DISEASEK12HD068369 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI SKAPEK, STEPHEN X · 2011 to 2020
$3.0MNICHD NIH HHS K12 HD068369NINDS NIH HHS R35 NS097333
Abstract
Secretagogin (SCGN) is a hexa-EF-hand protein that is highly expressed in the pancreas, brain, and gastrointestinal tract. SCGN is known to modulate regulated exocytosis in multiple cell lines and tissues; however, its exact functions and underlying mechanisms remain unclear. Here, we report that SCGN interacts with the plasma membrane SNARE SNAP-25, but not the assembled SNARE complex, in a Ca
Indexed as
ExocytosisAnimalsBinding SitesBrainCalciumCell LineCell MembraneGene Expression Regulation, DevelopmentalHumansMutationProtein BindingProtein ConformationSecretagoginsSynaptosomal-Associated Protein 25ZebrafishCalciumSecretagoginsSynaptosomal-Associated Protein 25neurological disorderneuronal developmentregulated exocytosisSNAP-25SNARE
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