ArticleProceedings of the National Academy of Sciences of the United States of America2020
Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
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- Time and dose selective glucose metabolism for glucose homeostasis and energy conversion in the liver.NPJ systems biology and applications · 2024Article
- Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses.Cell death and differentiation · 2024Article
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- Maternal nutrient metabolism in the liver during pregnancy.Frontiers in endocrinology · 2024Review
- Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and Chemoresistance.International journal of molecular sciences · 2023Review
- ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis.Nature communications · 2023Article
- The Effect of Human and Bovine Milk Osteopontin on Intestinal Caco-2 Cells: A Transcriptome Comparison.Nutrients · 2023Article
- Physiological and Pathophysiological Roles of Thioredoxin Interacting Protein: A Perspective on Redox Inflammation and Metabolism.Antioxidants & redox signaling · 2023Review
- Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis.Nature communications · 2023Article
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- Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease.Cellular and molecular gastroenterology and hepatology · 2023Article
- Salinity-induced transcriptome profiles in marine and freshwater threespine stickleback after an abrupt 6-hour exposure.Ecology and evolution · 2022Article
- Identification, tissue specific expression analysis and functional characterization of arrestin gene (ARRDC) in the earthworm Eudrilus eugeniae: a molecular hypothesis behind worm photoreception.Molecular biology reports · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Thiago M BatistaSection of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215.
Sezin DagdevirenDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.
Shannon H CarrollDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.
Weikang CaiSection of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215.
Veronika Y MelnikDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.
Hye Lim NohProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655.
Suchaorn SaengnipanthkulProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655.
Jason K KimProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655.
C Ronald KahnSection of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215; c.ronald.kahn@joslin.harvard.edu richard_lee@harvard.edu.
Richard T LeeDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138; c.ronald.kahn@joslin.harvard.edu richard_lee@harvard.edu.ORCID 0000-0003-4687-1381
Harvard University · USJoslin Diabetes Center · USUniversity of Massachusetts Chan Medical School · US
Funding
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI LAURIE J GOODYEAR · 1986 to 2026
$50.5MINSULIN RECEPTOR STRUCTURE AND TURNOVERR37DK031036 · NIDDK · JOSLIN DIABETES CENTER · PI KAHN, C RONALD · 2000 to 2019
$12.9MInsulin Receptor Substrates and Insulin ActionR01DK033201 · NIDDK · JOSLIN DIABETES CENTER · PI KAHN, C RONALD · 1986 to 2016
$10.6MUMass Mouse Metabolic Phenotyping Center - Metabolism CoreU2CDK093000 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2016 to 2021
$4.6MThe Insulin Receptor and Its Signaling MechanismsR01DK031036 · NIDDK · JOSLIN DIABETES CENTER · PI C RONALD KAHN · 1986 to 2026
$4.2MUMass Mouse Metabolic Phenotyping CenterU24DK093000 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2011 to 2015
$2.1MRegulation of Fructose Transport by Thioredoxin-Interacting ProteinR01DK107396 · NIDDK · HARVARD UNIVERSITY · PI LEE, RICHARD T · 2016 to 2020
$1.9MInterleukin-10 and Regulation of Skeletal Muscle Insulin ActionR01DK080756 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2008 to 2012
$1.6MRegulation of neural function by astrocyte insulin and IGF-1 receptor signalingK01DK120740 · NIDDK · NEW YORK INST OF TECHNOLOGY · PI CAI, WEIKANG · 2019 to 2021
$439kThe role of adipocyte alpha-arrestin ARRDC3 in obesityF32DK105682 · NIDDK · HARVARD UNIVERSITY · PI CARROLL, SHANNON · 2015 to 2016
$112kNIDDK NIH HHS F32 DK105682NIDDK NIH HHS K01 DK120740NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK031036NIDDK NIH HHS R01 DK033201NIDDK NIH HHS R01 DK080756NIDDK NIH HHS R01 DK107396NIDDK NIH HHS R37 DK031036NIDDK NIH HHS U24 DK093000NIDDK NIH HHS U2C DK093000
Abstract
Insulin action in the liver is critical for glucose homeostasis through regulation of glycogen synthesis and glucose output. Arrestin domain-containing 3 (
Indexed as
Insulin ResistanceAnimalsArrestinsCell MembraneForkhead Box Protein O1GlucoseHypoglycemic AgentsInsulinLiverMiceMice, Inbred C57BLMice, KnockoutPhosphorylationReceptor, InsulinARRDC3 protein, mouseArrestinsForkhead Box Protein O1Foxo1 protein, mouseGlucoseHypoglycemic AgentsInsulinReceptor, Insulinalpha arrestinsArrdc3glucose metabolisminsulin actionliver
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.