ArticleJournal of lipid research2020
Metabolic phospholipid labeling of intact bacteria enables a fluorescence assay that detects compromised outer membranes.
Article in Journal of lipid research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Bakuchiol killsFrontiers in pharmacology · 2025Article
- Reprogramming exosomes for immunity-remodeled photodynamic therapy against non-small cell lung cancer.Bioactive materials · 2024Article
- Unnatural lipids for simultaneous mRNA delivery and metabolic cell labeling.Biomaterials science · 2024Article
- Membrane staining and phospholipid tracking in Pseudomonas aeruginosa PAO1 using the phosphatidylcholine mimic propargyl-choline.Access microbiology · 2024Article
- Combining lipid-mimicking-enabled transition metal and enzyme-mediated catalysis at the cell surface ofChemical science · 2023Article
- Mechanism of outer membrane destabilization by global reduction of protein content.Nature communications · 2023Article
- Mechanism of outer membrane destabilization by global reduction of protein content.bioRxiv : the preprint server for biology · 2023Article
- Using click chemistry to study microbial ecology and evolution.ISME communications · 2023Review
- Metabolic Incorporation of Azido-Sugars into LPS to Enable Live-Cell Fluorescence Imaging.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Engineered Cell Membrane-Derived Nanocarriers: The Enhanced Delivery System for Therapeutic Applications.Frontiers in cell and developmental biology · 2022Review
- Emerging Approaches to Functionalizing Cell Membrane-Coated Nanoparticles.Biochemistry · 2021Review
- Studying the surfaces of bacteria using neutron scattering: finding new openings for antibiotics.Biochemical Society transactions · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gram-negative bacteria possess an asymmetric outer membrane (OM) composed primarily of lipopolysaccharides (LPSs) on the outer leaflet and phospholipids (PLs) on the inner leaflet. The loss of this asymmetry due to mutations in the LPS biosynthesis or transport pathways causes the externalization of PLs to the outer leaflet of the OM and leads to OM permeability defects. Here, we used metabolic labeling to detect a compromised OM in intact bacteria. Phosphatidylcholine synthase expression in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.