Evidence map›Paper›PMID 32156702›Full record

ArticleThe Journal of biological chemistry2020

Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin.

Ashoka A Maddur, Heather K Kroh, Mary E Aschenbrenner, Breanne H Y Gibson, Peter Panizzi, Jonathan H Sheehan, Jens Meiler, Paul E Bock, Ingrid M Verhamme

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ashoka A MaddurDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2561. Electronic address: ashoka.maddur@vumc.org.
Heather K KrohDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2561.
Mary E AschenbrennerDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2561.
Breanne H Y GibsonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2561.
Peter PanizziDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, Alabama 36849.
Jonathan H SheehanCenter for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232.
Jens MeilerCenter for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232; Institute for Drug Discovery, Departments of Chemistry and Computer Science, Leipzig University Medical School, SAC 04103 Leipzig, Germany.
Paul E BockDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2561.
Ingrid M VerhammeDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2561. Electronic address: ingrid.verhamme@vanderbilt.edu.
Vanderbilt University Medical Center · USVanderbilt University · USAuburn University · US

Funding

Decrypting Variants of Uncertain Significance in Long-QT SyndromeR01HL122010 · NHLBI · VANDERBILT UNIVERSITY · PI GEORGE, ALFRED L., SANDERS, CHARLES R · 2014 to 2025
$15.5M
Mechanism of Staphylocoagulase-activated Blood ClottingR01HL071544 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BOCK, PAUL E, VERHAMME, INGRID M · 2003 to 2016
$1.8M
Pathogen specific imaging of endocarditisR01HL114477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS, PANIZZI, PETER ROLF · 2013 to 2016
$1.7M
NHLBI NIH HHS R01 HL071544NHLBI NIH HHS R01 HL114477NHLBI NIH HHS R01 HL122010
6 · The paper itself

Abstract

In

Indexed as

Bacterial ProteinsBinding SitesCoagulaseHumansModels, MolecularProtein BindingProthrombinStaphylococcal InfectionsStaphylococcus aureusSubstrate SpecificityBacterial ProteinsCoagulaseProthrombinaffinityclot formationcoagulationcoagulation factorcompetitive equilibrium bindingendocarditisequilibrium bindingfibrinkineticsligand-binding proteinprothrombinspecificitystaphylocoagulase (SC)Staphylococcus aureus (S. aureus)virulence factor

Identifiers

PMID32156702
PMCPMC7186164
OpenAlexW3011375013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.