Observational studyBMC cardiovascular disorders2020
Heparin-binding protein measurement improves the prediction of myocardial injury-related cardiogenic shock.
Observational study in BMC cardiovascular disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Kinetics and prognostic value of heparin binding protein at the ST-segment-elevation myocardial infarction.Annals of medicine · 2026Article
- Longitudinal Analysis of Heparin-Binding Protein (HBP) and Serum Amyloid a Protein (SAA) Versus Interleukin 6 (IL-6), C-Reactive Protein (CRP), and Procalcitonin (PCT) During Both the Acute Postoperative Period and Recovery at Three Months From Non-emergent Cardiac Surgery.Clinical Medicine Insights. Cardiology · 2026Article
- Heparin Binding Protein in Sepsis-A Comprehensive Overview of Pathophysiology, Clinical Usage and Utility as Biomarker.Biomedicines · 2025Review
- Risk factors and predictive nomogram for multi-organ failure in patients with acute kidney failure combined with severe sepsis.American journal of translational research · 2025Article
- Association of heparin-binding protein with risk of in-hospital heart failure in patients with acute coronary syndrome.American journal of translational research · 2025Article
- Heparin-binding Protein as a Diagnostic and Prognostic Marker of Infections: A Systematic Review and Meta-analysis.Mediterranean journal of hematology and infectious diseases · 2025Review
- Postoperative hyper-inflammation as a predictor of poor outcomes in patients with acute type A aortic dissection (ATAAD) undergoing surgical repair.Journal of cardiothoracic surgery · 2024Article
- The effect of heparins on plasma concentration of heparin-binding protein: a pilot study.BJA open · 2024Article
- Sivelestat in Patients at a High Risk of Postoperative Acute Lung Injury After Scheduled Cardiac Surgery: A Prospective Cohort Study.Journal of inflammation research · 2024Article
- Utility of heparin-binding protein following cardiothoracic surgery using cardiopulmonary bypass.Scientific reports · 2023Observational
- Risk factors for postoperative myocardial injury-related cardiogenic shock in patients undergoing cardiac surgery.Journal of cardiothoracic surgery · 2023Article
- The neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury in patients with cardiopulmonary bypass.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHeparin-binding protein (HBP), a potent inducer of increased vascular permeability, is a potentially useful biomarker for predicting outcomes in patients with postoperative myocardial injury-related cardiogenic shock (MIRCS). We aimed to evaluate and validate HBP as a prognostic biomarker for postoperative MIRCS.
methodsWe performed a case-control study in 792 patients undergoing cardiac surgery from January 1, 2016, to August 1, 2019, including 172 patients with postoperative MIRCS and 620 age- and sex-matched controls. The association between HBP and MIRCS was determined by multivariate logistic regression analysis. Receiver operating characteristic curves (ROCs) with area under the curve (AUC) were performed to calculate the cut-off value, sensitivity and specificity. The association between HBP and cardiac troponin T (cTnT) was determined by multivariable linear regression analysis. Blood samples were drawn from the coronary sinus and arterial line of the cardiopulmonary bypass (CPB) before aortic cross-clamping (time point 1) and 5 min after aortic declamping (time point 2).
resultsBefore aortic cross-clamping, coronary sinus HBP (HBP
conclusionsElevated levels of coronary sinus HBP were useful biomarkers for predicting MIRCS after cardiac surgery.
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