ReviewDiagnostics (Basel, Switzerland)2020
The Influence of Thyroid Pathology on Osteoporosis and Fracture Risk: A Review.
Review in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- The relationship of hip fracture and thyroid disorders: a systematic review.Frontiers in endocrinology · 2023Pooled it
- Dietary mineral insufficiency and osteoporosis risk across skeletal sites in older Iranian adults: IMOS-2021.Journal of bone and mineral metabolism · 2026Article
- Association Between Hypothyroidism and Postoperative Complications Following Operative Ankle Fracture Fixation: A Retrospective Cohort Study.Foot & ankle orthopaedics · 2026Article
- Bone mineral density testing rates and fracture risk across cancers with different mortality risks: a nationwide matched cohort study.Archives of osteoporosis · 2026Article
- Osteoporosis independent of traditional risk factors in hyperthyroid patients in a resource-limited setting: An observational study.Medicine · 2026Observational
- Stress fracture of the neck of talus in an adolescent female with hypothyroidism: a case report of an unusual cause of ankle pain.International journal of surgery case reports · 2026Article
- Hypothyroidism in adult spinal deformity.Spine deformity · 2026Article
- Circulating Wnt Signaling Inhibitors and Osteoprotegerin in Women with Newly Diagnosed Overt Thyroid Dysfunction.Metabolites · 2026Article
- Neural regulation of bone: from central neural circuits to peripheral innervation of the skeletal stem cell niche.Bone research · 2026Review
- PrOsteoporosis: predicting osteoporosis risk using NHANES data and machine learning approach.BMC research notes · 2025Article
- Association between sensitivity to thyroid hormones and trabecular bone score in euthyroid individuals: a population-based cross-sectional study.BMC musculoskeletal disorders · 2024Article
- Beyond the Thyroid: A Narrative Review of Extra-thyroidal Manifestations in Hashimoto's Disease.Cureus · 2024Review
- Psychological Disorders Linked to Osteoporosis Diagnoses in a Population-Based Cohort Study of Middle and Older Age United States Adults.The Gerontologist · 2024Article
- Evaluation of Bone Health in Postmenopausal Women Using Long-Term Levothyroxine Treatment Due to Post-Procedural Hypothyroidism.International journal of general medicine · 2024Article
- Mechanisms and Treatment Options for Hyperthyroid-Induced Osteoporosis: A Narrative Review.Cureus · 2023Review
- Is thyroid disease associated with post-operative complications after total joint arthroplasty? A systematic review of the literature.EFORT open reviews · 2023Review
- Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism.Scientific reports · 2023Article
- Impact of seborrheic dermatitis on osteoporosis risk: A population-based cohort study.The Journal of dermatology · 2022Article
- Low Bone Turnover Due to Hypothyroidism or Anti-Resorptive Treatment Does Not Affect Whole-Body Glucose Homeostasis in Male Mice.Journal of personalized medicine · 2022Article
- Association of decreased muscle mass with reduced bone mineral density in patients with Graves' disease.Endocrine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormones are important factors that regulate metabolism and cell differentiation throughout the human body. A complication of thyroid pathology is represented by an alteration of the bone metabolism which can lead to osteoporosis and fragility fractures, known to have a high mortality rate. Although there is a consensus on the negative impact of hyperthyroidism on bone metabolism, when referring to hypothyroidism, subclinical hypothyroidism, or subclinical hyperthyroidism, there is no general agreement. The aim of our review was to update clinicians and researchers about the current data regarding the bone health in hypothyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism patients. Thyroid disorders have an important impact on bone metabolism and fracture risk, such that hyperthyroidism, hypothyroidism, and subclinical hyperthyroidism are associated with a decreased bone mineral density (BMD) and increased risk of fracture. Subclinical hypothyroidism, on the other hand, is not associated with osteoporosis or fragility fractures, and subclinical hyperthyroidism treatment with radioiodine could improve bone health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.