ArticleDiagnostics (Basel, Switzerland)2020
Can Strain Elastography Predict Malignancy of Soft Tissue Tumors in a Tertiary Sarcoma Center?
Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Elastosonography in the Differential Diagnosis of Musculoskeletal Soft Tissue Tumors: A Systematic Review.Journal of clinical medicine · 2026Review
- MixTURE: L1-Norm-Based Mixed Second-Order Continuity in Strain Tensor Ultrasound Elastography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- A multiparametric clinic-ultrasomics nomogram for predicting extremity soft-tissue tumor malignancy: a combined retrospective and prospective bicentric study.La Radiologia medica · 2023Article
- A human pilot study on positive electrostatic charge effects in solid tumors of the late-stage metastatic patients.Frontiers in medicine · 2023Article
- Differentiation of benign and malignant superficial soft tissue lesions using real-time strain elastographyTurkish journal of medical sciences · 2021Article
- The diagnostic performance of conventional ultrasound and strain elastography in malignant soft tissue tumors.Skeletal radiology · 2021Article
- Reply to Comment on Diagnostic Accuracy of a Sonographic Scoring System in Predicting the Malignant Potential of a Soft-tissue Swelling.Journal of medical ultrasoundArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to investigate the ability of ultrasound strain elastography as an adjunct to predict malignancy in soft tissue tumors suspect of sarcoma or metastasis in a tertiary reference center for sarcoma. A total of 137 patients were included prospectively. Patients were referred on the basis of clinical or radiological suspicion of malignant soft tissue tumor. All patients had previously undergone diagnostic imaging (MRI, CT or PET-CT). After recording strain elastography cine loops, ultrasound guided biopsy was performed. Three investigators, who were blinded to final diagnosis, reviewed all elastograms retrospectively. For each elastogram, a qualitative, visual 5-point score was decided in consensus and a strain ratio was calculated. Final pathology obtained from biopsy or tumor resection served as gold standard. Eighty-one tumors were benign, and 56 were malignant. t-tests showed a significant difference in mean visual score between benign and malignant tumors. There was no significant difference in mean strain ratio between the two groups. Strain elastography may be a valuable adjunct to conventional B-mode ultrasound, perhaps primarily in primary care, when considering whether to refer to a sarcoma center or to biopsy, although biopsies cannot reliably be ruled out based on the current data.
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Registered trials
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