ReviewMaterials (Basel, Switzerland)2020
Bio-Inductive Materials in Direct and Indirect Pulp Capping-A Review Article.
Review in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06256601 (A Clinical Investigation of the Effectiveness of a Calcium Silicate Cement Used in the Treatment of Deep Lesions), which is not on this map. Cited by 118 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Clinical Investigation of the Effectiveness of a Calcium Silicate Cement Used in the Treatment of Deep Lesions
Who cites it
118 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Pooled it
- Calcium silicate liner versus no liner in selective caries removal: a one-year randomized clinical trial.BMC oral health · 2026Trial
- Trial
- Trial
- Histopathological and immunohistochemical characterization of pulp tissue reaction to ACTIVA BioACTIVE base/liner in primary teeth pulpotomy: a randomized clinical trial.BMC oral health · 2025Trial
- 3-year randomized clinical trial to evaluate the performance of posterior composite restorations lined with ion-releasing materials.Scientific reports · 2024Trial
- The Outcome of GaAlAs Diode Laser (980 Nm) Pulpotomy in Patients with Symptomatic Irreversible Pulpitis Assessed Using CBCT - Randomised Controlled Trial with an 18-Month Follow-up.European endodontic journal · 2024Trial
- Efficacy of Platelet Rich Plasma and Platelet Rich Fibrin for Direct Pulp Capping in Adult Patients with Carious Pulp Exposure- A Randomised Controlled Trial.European endodontic journal · 2022Trial
- Mineral Trioxide AggregateIranian endodontic journal · 2022Trial
- Clinical decision-making in pulp therapy of primary teeth among Tunisian dental practitioners: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Trends and Future Perspectives in Additive Modifications of Calcium Silicate-Based Cements: A Scoping Review (2015-2024).Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026Article
- Tooth discoloration potential of different pulp capping materials in direct and indirect pulp capping procedures: a spectrophotometric in vitro study.BMC oral health · 2026Article
- Dose-dependent effects of Metformin on proliferation and odontogenic differentiation of dental pulp stem cells.BMC oral health · 2026Article
- Therapy and material choices in pulp exposure among public dentists in Norway.Acta odontologica Scandinavica · 2026Article
- In Vitro Evaluation of Novel Resin-Modified Calcium Silicate Cements for Minimally Invasive Vital Pulp Therapy.International dental journal · 2026Article
- Comparative success of platelet-rich fibrin and mineral trioxide aggregate in direct pulp capping and pulpotomy: a systematic review and meta-analysis.Biomaterial investigations in dentistry · 2026Review
- Hard tissue barrier detection in permanent mandibular molars that have undergone direct pulp capping and partial pulpotomy: A retrospective cohort study.Journal of dental sciences · 2026Article
- Effect of maturation time and adhesive system on the shear bond strength and failure modes of Biodentine™ bonded with resin composite and glass ionomer cement.Biomaterial investigations in dentistry · 2026Article
- The Function and Role of Intercellular Adhesion Molecule 2 in Dental Pulp Cells and Tissue.International journal of molecular sciences · 2025Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The article is aimed at analyzing the available research and comparing the properties of bio-inductive materials in direct and indirect pulp capping procedures. The properties and clinical performances of four calcium-silicate cements (ProRoot MTA, MTA Angelus, RetroMTA, Biodentine), a light-cured calcium silicate-based material (TheraCal LC) and an enhanced resin-modified glass-ionomer (ACTIVA BioACTIVE) are widely discussed. A correlation of in vitro and in vivo data revealed that, currently, the most validated material for pulp capping procedures is still MTA. Despite Biodentine's superiority in relatively easier manipulation, competitive pricing and predictable clinical outcome, more long-term clinical studies on Biodentine as a pulp capping agent are needed. According to available research, there is also insufficient evidence to support the use of TheraCal LC or ACTIVA BioACTIVE BASE/LINER in vital pulp therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.