ArticleCells2020
Fabrication of Dentin-Pulp-Like Organoids Using Dental-Pulp Stem Cells.
Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- A Novel piRNA-Mediated Epigenetic Axis: piR-36241 Exacerbates Pulpitis by Silencing the Protective Receptor ADGRG2 in Human Dental Pulp Stem Cells.International endodontic journal · 2026Article
- Stem cell-driven biomedical technologies for tooth regeneration: engineering scaffolds, organoid models, and molecular targeted strategies.Stem cell research & therapy · 2026Review
- Comparative evaluation of 3D culture strategies for pulp-dentin models.BMC oral health · 2026Article
- Three-Dimensional Models of the Dental Pulp: Bridging Fundamental Biology and Regenerative Therapy.International journal of molecular sciences · 2025Review
- Article
- 3D histology of human heart-forming organoids by X-ray phase-contrast tomography.Communications biology · 2025Article
- Optimizing methods for regenerative endodontics.Regenerative medicine · 2025Review
- Cell condensation initiates organogenesis: the role of actin dynamics in supracellular self-organizing process.Cell & bioscience · 2025Review
- Organoid in dentistry: Models for oral biology and disease.Journal of dental sciences · 2025Review
- Potential Implications of Organoids in Dental Research.Frontiers in dentistry · 2025Review
- Organoids in the oral and maxillofacial region: present and future.International journal of oral science · 2024Review
- Simple and Cost-Effective Generation of 3D Cell Sheets and Spheroids Using Curvature-Controlled Paraffin Wax Substrates.Nano convergence · 2024Article
- Self-assembly of differentiated dental pulp stem cells facilitates spheroid human dental organoid formation and prevascularization.World journal of stem cells · 2024Article
- Revolutionising oral organoids with artificial intelligence.Biomaterials translational · 2024Review
- 3D Organoids for Regenerative Endodontics.Biomolecules · 2023Review
- Epithelium-derived SCUBE3 promotes polarized odontoblastic differentiation of dental mesenchymal stem cells and pulp regeneration.Stem cell research & therapy · 2023Article
- Mechanical Regulation of Oral Epithelial Barrier Function.Bioengineering (Basel, Switzerland) · 2023Article
- Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue.NPJ Regenerative medicine · 2023Article
- Fabrication of functional ameloblasts from hiPSCs for dental application.Frontiers in cell and developmental biology · 2023Article
- Mammalian dental diversity: an evolutionary template for regenerative dentistry.Frontiers in dental medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We developed a novel dentin-pulp-like organoid. It has both stem-cell and odontoblast characteristics using a mesenchymal cell lineage of human dental-pulp stem cells (hDPSCs). The mixture of hDPSCs and Matrigel was transferred into the maintenance medium (MM) and divided into four different groups according to how long they were maintained in the odontogenic differentiation medium (ODM). All organoids were harvested at 21 days and analyzed to find the optimal differentiation condition. To assess the re-fabrication of dentin-pulp-like organoid, after dissociation of the organoids, it was successfully regenerated. Additionally, its biological activity was confirmed by analyzing changes of relevant gene expression and performing a histology analysis after adding Biodentine
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.