Evidence map›Paper›PMID 32155787›Full record

ArticleDiagnostics (Basel, Switzerland)2020

Circulating Tumor Cells as a Tool of Minimal Residual Disease Can Predict Lung Cancer Recurrence: A longitudinal, Prospective Trial.

Ching-Yang Wu, Chia-Lin Lee, Ching-Feng Wu, Jui-Ying Fu, Cheng-Ta Yang, Chi-Tsung Wen, Yun-Hen Liu, Hui-Ping Liu, Jason Chia-Hsun Hsieh

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06262386 (Utilizing Perioperative Variation Trends of Circulating Tumor Cells and Tumor Pathological Characteristics as a Combined Relapse Prediction Model for Resectable Non-Small Cell Patients - a Prospective Clinical Feasibility Trial), which is not on this map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06262386 narecruitingnot on this mapstarted 2023, after this paper: background citation

Utilizing Perioperative Variation Trends of Circulating Tumor Cells and Tumor Pathological Characteristics as a Combined Relapse Prediction Model for Resectable Non-Small Cell Patients - a Prospective Clinical Feasibility Trial

TypeinterventionalSponsorChang Gung Memorial HospitalRan2023 to 2028Enrolled358ConditionsLung Cancer, Relapse/RecurrenceArmsCisplatin based chemottherapy
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Liquid biopsy techniques and lung cancer: diagnosis, monitoring and evaluation.Journal of experimental & clinical cancer research : CR · 2024
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ching-Yang WuDivision of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou 333423, Taiwan.
Chia-Lin LeeDepartment of Medicine, School of Medicine, National Yang-Ming University, Taipei 112304, Taiwan.
Ching-Feng WuDivision of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou 333423, Taiwan.
Jui-Ying FuCollege of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.
Cheng-Ta YangCollege of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.ORCID 0000-0003-1846-1027
Chi-Tsung WenDivision of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou 333423, Taiwan.
Yun-Hen LiuDivision of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou 333423, Taiwan.
Hui-Ping LiuDivision of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou 333423, Taiwan.
Jason Chia-Hsun HsiehCollege of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.ORCID 0000-0002-5547-409X
Chang Gung University · TWNational Yang Ming Chiao Tung University · TW

Funding

Chang Gung Memorial Hospital, Linkou CMRPG3G0591-3Chang Gung Memorial Hospital, Linkou CMRPG3H1681Chang Gung Memorial Hospital, Linkou CORPG3G0771Ministry of Science and Technology, Taiwan 108-2628-B-182A-001
6 · The paper itself

Abstract

backgroundThe role of circulating tumor cells (CTCs) for predicting the recurrence of cancer in lung cancer patients after surgery remains unclear.

methodsA negatively selected protocol of CTC identification was applied. For all the enrolled patients, CTC testing was performed before and after surgery on the operation day (day 0), postoperative day 1, and day 3. The daily decline and trend of CTCs were analyzed to correlate with cancer relapse. The mixed model repeated measures (MMRM) adjusted by cancer characteristics was applied for statistical significance.

resultsFifty patients with lung mass undergoing surgery were enrolled. Among 41 primary lung cancers, 26 (63.4%) were pathological stage Tis and I. A total of 200 CTC tests were performed. MMRM analysis indicated that surgery could contribute to a CTC decline after surgery in all patients with statistical significance (

conclusionCTC testing can potentially serve as a tool for minimal residual disease detection in early-staged lung cancer after curative surgery.

Indexed as

circulating tumor cellsearly detectionearly-stageminimal residual disease’ mixed model repeated measuresnon-small cell lung cancer

Identifiers

PMID32155787
PMCPMC7151004
OpenAlexW3009614224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.