Evidence map›Paper›PMID 32155768›Full record

ArticleMarine drugs2020

Synthesis, Pharmacological and Structural Characterization of Novel Conopressins from

Julien Giribaldi, Lotten Ragnarsson, Tom Pujante, Christine Enjalbal, David Wilson, Norelle L Daly, Richard J Lewis, Sebastien Dutertre

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Cone snail species off the Brazilian coast and their venoms: a review and update.The journal of venomous animals and toxins including tropical diseases · 2023
    Review
  7. Isolation and characterization of five novel disulfide-poor conopeptides fromThe journal of venomous animals and toxins including tropical diseases · 2022
    Article
  8. Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Julien GiribaldiInstitut des Biomolécules Max Mousseron, UMR 5247, Université de Montpellier-CNRS, 34095 Montpellier, France.ORCID 0000-0002-4273-3080
Lotten RagnarssonInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.
Tom PujanteInstitut des Biomolécules Max Mousseron, UMR 5247, Université de Montpellier-CNRS, 34095 Montpellier, France.
Christine EnjalbalInstitut des Biomolécules Max Mousseron, UMR 5247, Université de Montpellier-CNRS, 34095 Montpellier, France.ORCID 0000-0003-4646-4583
David WilsonCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD 4878, Australia.
Norelle L DalyCentre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD 4878, Australia.ORCID 0000-0002-4697-6602
Richard J LewisInstitute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.ORCID 0000-0003-3470-923X
Sebastien DutertreInstitut des Biomolécules Max Mousseron, UMR 5247, Université de Montpellier-CNRS, 34095 Montpellier, France.ORCID 0000-0002-2945-1484
Centre National de la Recherche Scientifique · FRAustralian Institute of Tropical Health and Medicine · AUThe University of Queensland · AU

Funding

Agence Nationale de la Recherche ANR-16-CE34-0002
6 · The paper itself

Abstract

Cone snails produce a fast-acting and often paralyzing venom, largely dominated by disulfide-rich conotoxins targeting ion channels. Although disulfide-poor conopeptides are usually minor components of cone snail venoms, their ability to target key membrane receptors such as GPCRs make them highly valuable as drug lead compounds. From the venom gland transcriptome of

Indexed as

Amino Acid SequenceAnimalsConotoxinsConus SnailDisulfidesHumansMolecular ConformationMollusk VenomsNeurophysinsProtein PrecursorsReceptors, OxytocinReceptors, VasopressinStructure-Activity RelationshipTranscriptomeVasopressinsZebrafishAVP protein, humanConotoxinsDisulfidesMollusk VenomsNeurophysinsProtein PrecursorsReceptors, OxytocinReceptors, VasopressinVasopressinscone snailconopressinconotoxinvasopressinvenom

Identifiers

PMID32155768
PMCPMC7143535
OpenAlexW3009192289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.