ReviewTrends in genetics : TIG2020
The Telomere Paradox: Stable Genome Preservation with Rapidly Evolving Proteins.
Review in Trends in genetics : TIG, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Convergence and conflict among telomere-specialized transposons across 60 million years of Drosophilid evolution.Genome research · 2026Article
- Noncanonical chromosomal-end-specific telomeric repeat arrays in naturally telomerase-negative yeasts.Nucleic acids research · 2026Article
- The genome sequence of the gastric gland parasite,iScience · 2026Article
- A GWAS-machine learning framework reveals protein-synthesis pathway signals for yield in Theobroma cacao after population-structure correction.Scientific reports · 2026Article
- Improved genome assembly of whale shark, the world's biggest fish: revealing intragenomic heterogeneity in molecular evolution.GigaScience · 2026Article
- Robust Binding Capability and Occasional Gene Loss of Telomere-Binding Proteins Underlying Telomere Evolution in Nematoda.Genome biology and evolution · 2025Article
- Novel centromeric repetitive DNA elements reveal karyotype dynamics in polyploid sainfoin (Onobrychis viciifolia).Chromosoma · 2024Article
- A non-canonical role of the inner kinetochore in regulating sister-chromatid cohesion at centromeres.The EMBO journal · 2024Article
- Does Effective Population Size Govern Evolutionary Differences in Telomere Length?Genome biology and evolution · 2024Article
- Subtelomeric plasticity contributes to gene family expansion in the human parasitic flatworm Schistosoma mansoni.BMC genomics · 2024Article
- No end in sight: Mysteries of the telomeric variation in plants.American journal of botany · 2023Article
- Relationship between aging and control of metabolic syndrome with telomere shortening: a cross-sectional study.Scientific reports · 2023Article
- Article
- POT-3 preferentially binds the terminal DNA-repeat on the telomeric G-overhang.Nucleic acids research · 2023Article
- Meiotic drive in house mice: mechanisms, consequences, and insights for human biology.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Review
- Plant telomere biology: The green solution to the end-replication problem.The Plant cell · 2022Article
- Functional Diversification of Chromatin on Rapid Evolutionary Timescales.Annual review of genetics · 2021Review
- Telomeric and Sub-Telomeric Structure and Implications in Fungal Opportunistic Pathogens.Microorganisms · 2021Review
- Structural genomics approach to investigate deleterious impact of nsSNPs in conserved telomere maintenance component 1.Scientific reports · 2021Article
- The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1.Nature communications · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Telomeres ensure chromosome length homeostasis and protection from catastrophic end-to-end chromosome fusions. All eukaryotes require this essential, strictly conserved telomere-dependent genome preservation. However, recent evolutionary analyses of mammals, plants, and flies report pervasive rapid evolution of telomere proteins. The causes of this paradoxical observation - that unconserved machinery underlies an essential, conserved function - remain enigmatic. Indeed, these fast-evolving telomere proteins bind, extend, and protect telomeric DNA, which itself evolves slowly in most systems. We hypothesize that the universally fast-evolving subtelomere - the telomere-adjacent, repetitive sequence - is a primary driver of the 'telomere paradox'. Under this model, radical sequence changes in the subtelomere perturb subtelomere-dependent, telomere functions. Compromised telomere function then spurs adaptation of telomere proteins to maintain telomere length homeostasis and protection. We propose an experimental framework that leverages both protein divergence and subtelomeric sequence divergence to test the hypothesis that subtelomere sequence evolution shapes recurrent innovation of telomere machinery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.