ArticleNeuron2020
Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 2 of them syntheses that pooled it.
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Who cites it
141 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- The influence of emotional stimuli on response inhibition: a systematic review in non-clinical adults.Frontiers in psychology · 2025Pooled it
- Dopamine amplifies subthalamic long-latency responses to cortical stimulation in patients with Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Has stopping stopped making sense? Disentangling the processes elicited by complex action cancellation paradigms.Cognitive, affective & behavioral neuroscience · 2026Review
- Cortical Contributions to Attentional Orienting and Response Cancellation in Action Stopping.Psychophysiology · 2026Article
- High frequency electrical stimulation paces fast spiking interneurons and modulates cellular information processing.Communications biology · 2026Article
- Distinct temporal patterns of beta bursts differentiate successful and failed movement cancellation.iScience · 2026Article
- Neuroimaging evidence for a dopamine-independent association between motor cortex microstructure and Parkinson's disease severity.NPJ Parkinson's disease · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Characterising motor and cognitive contributions of cortical beta oscillations and their modulation with rTMS.NeuroImage · 2026Article
- Neurons of the human subthalamic nucleus engage with local delta frequency processes during action cancellation.Nature communications · 2026Article
- A cortico-subthalamic circuit rapidly engages and releases inhibition of specific movements depending on the environmental context.PLoS biology · 2026Article
- β-Bursting as a Sensitive Neural Marker of Inhibitory Control in Healthy Older Adults: A Linear Mixed-Effects Modeling and Threshold-Free Cluster Approach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dynamic modeling in neurocognitive frameworks of childhood ADHD: a review of inhibitory control and reward systems.Translational psychiatry · 2026Review
- Deep brain stimulation reduces subthalamic nucleus pathological dynamics and rescues gait deficits associated with dopamine loss.bioRxiv : the preprint server for biology · 2026Article
- The striatal indirect pathway mediates hesitation.Nature neuroscience · 2026Article
- Clinical utility of evoked potentials for programming subthalamic deep brain stimulation in Parkinsons disease.NPJ Parkinson's disease · 2026Review
- Cortico-basal ganglia dynamics of global and selective response inhibition in humans.bioRxiv : the preprint server for biology · 2026Article
- Unraveling the mystery of stuttering: clinical and physiological insights into its manifestation.Frontiers in human neuroscience · 2026Article
- Hyperdirect projections from the supplementary motor area mediate subthalamic stimulation effects on movement initiation and inhibition in Parkinson's disease.Brain communications · 2026Article
81 more citing papers are in PubMed but not listed here.
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8 authors.
Funding
Abstract
The ability to dynamically change motor outputs, such as stopping an initiated response, is an important aspect of human behavior. A hyperdirect pathway between the inferior frontal gyrus and subthalamic nucleus is hypothesized to mediate movement inhibition, but there is limited evidence for this in humans. We recorded high spatial and temporal resolution field potentials from both the inferior frontal gyrus and subthalamic nucleus in 21 subjects. Cortical potentials evoked by subthalamic stimulation revealed short latency events indicative of monosynaptic connectivity between the inferior frontal gyrus and ventral subthalamic nucleus. During a stop signal task, stopping-related potentials in the cortex preceded stopping-related activity in the subthalamic nucleus, and synchronization between these task-evoked potentials predicted the stop signal reaction time. Thus, we show that a prefrontal-subthalamic hyperdirect pathway is present in humans and mediates rapid stopping. These findings may inform therapies to treat disorders featuring perturbed movement inhibition.
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