Evidence map›Paper›PMID 32155414›Full record

ArticleCurrent biology : CB2020

Two MYB Proteins in a Self-Organizing Activator-Inhibitor System Produce Spotted Pigmentation Patterns.

Baoqing Ding, Erin L Patterson, Srinidhi V Holalu, Jingjian Li, Grace A Johnson, Lauren E Stanley, Anna B Greenlee, Foen Peng, H D Bradshaw, Michael L Blinov and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
26.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 137 citations in OpenAlex.

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  3. The genetic and developmental enigma of rhizomes: crucial traits with limited understanding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Baoqing DingDepartment of Ecology and Evolutionary Biology, University of Connecticut, 75 North Eagleville Road, Unit 3043, Storrs, CT 06269, USA.
Erin L PattersonDepartment of Plant and Microbial Biology, University of California, Berkeley, 111 Koshland Hall #3102, Berkeley, CA 94720, USA; Department of Biology, University of Virginia, P.O. Box 400328, Charlottesville, VA 22904, USA.
Srinidhi V HolaluDepartment of Plant and Microbial Biology, University of California, Berkeley, 111 Koshland Hall #3102, Berkeley, CA 94720, USA; Department of Biology, University of Virginia, P.O. Box 400328, Charlottesville, VA 22904, USA.
Jingjian LiDepartment of Ecology and Evolutionary Biology, University of Connecticut, 75 North Eagleville Road, Unit 3043, Storrs, CT 06269, USA; College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China.
Grace A JohnsonDepartment of Plant and Microbial Biology, University of California, Berkeley, 111 Koshland Hall #3102, Berkeley, CA 94720, USA.
Lauren E StanleyDepartment of Ecology and Evolutionary Biology, University of Connecticut, 75 North Eagleville Road, Unit 3043, Storrs, CT 06269, USA.
Anna B GreenleeDepartment of Biology, University of Virginia, P.O. Box 400328, Charlottesville, VA 22904, USA.
Foen PengDepartment of Biology, University of Washington, Box 351800, Seattle, WA 98195, USA.
H D BradshawDepartment of Biology, University of Washington, Box 351800, Seattle, WA 98195, USA.
Michael L BlinovCenter for Cell Analysis and Modeling, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.
Benjamin K BlackmanDepartment of Plant and Microbial Biology, University of California, Berkeley, 111 Koshland Hall #3102, Berkeley, CA 94720, USA; Department of Biology, University of Virginia, P.O. Box 400328, Charlottesville, VA 22904, USA. Electronic address: bkblackman@berkeley.edu.
Yao-Wu YuanDepartment of Ecology and Evolutionary Biology, University of Connecticut, 75 North Eagleville Road, Unit 3043, Storrs, CT 06269, USA; Institute for Systems Genomics, University of Connecticut, 67 North Eagleville Road, Storrs, CT 06269, USA. Electronic address: yaowu.yuan@uconn.edu.
University of Connecticut · USUniversity of Virginia · USUniversity of California, Berkeley · USUniversity of Washington · USUConn Health · US

Funding

TR&D4 Spatial Modeling: Modeling Framework for Cell MotilityP41GM103313 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LOEW, LESLIE M · 2012 to 2018
$9.7M
Genetic origin, developmental mechanism, and evolutionary process of a novel phenotype in Mimulus (monkeyflowers)R01GM131055 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI YUAN, YAOWU · 2019 to 2023
$1.6M
Genetics of prezygotic reproductive isolation in natural populations of monkR01GM088805 · NIGMS · UNIVERSITY OF WASHINGTON · PI BRADSHAW, H.D. TOBY, SCHEMSKE, DOUGLAS · 2010 to 2013
$1.2M
Pacific Biosciences PacBio RS Single Molecule Real Time SequencerS10OD018174 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROKHSAR, DANIEL SOLEYMAN · 2014 to 2014
$600k
The Virtual Cell: a Computational Resource for Collaborative Modeling and Simulation of Cell BiologyR24GM134211 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LOEW, LESLIE M · 2019 to 2019
$528k
NIGMS NIH HHS P41 GM103313NIGMS NIH HHS R01 GM088805NIGMS NIH HHS R01 GM131055NIGMS NIH HHS R24 GM134211NIH HHS S10 OD018174
6 · The paper itself

Abstract

Many organisms exhibit visually striking spotted or striped pigmentation patterns. Developmental models predict that such spatial patterns can form when a local autocatalytic feedback loop and a long-range inhibitory feedback loop interact. At its simplest, this self-organizing network only requires one self-activating activator that also activates a repressor, which inhibits the activator and diffuses to neighboring cells. However, the molecular activators and inhibitors fully fitting this versatile model remain elusive in pigmentation systems. Here, we characterize an R2R3-MYB activator and an R3-MYB repressor in monkeyflowers (Mimulus). Through experimental perturbation and mathematical modeling, we demonstrate that the properties of these two proteins correspond to an activator-inhibitor pair in a two-component, reaction-diffusion system, explaining the formation of dispersed anthocyanin spots in monkeyflower petals. Notably, disrupting this pattern impacts pollinator visitation. Thus, subtle changes in simple activator-inhibitor systems are likely essential contributors to the evolution of the remarkable diversity of pigmentation patterns in flowers.

Indexed as

MimulusPigmentationPigments, BiologicalPlant ProteinsProto-Oncogene Proteins c-mybTranscription FactorsPigments, BiologicalPlant ProteinsProto-Oncogene Proteins c-mybTranscription Factorsanthocyanindevelopmental patterningErythrantheflower colorgenome editingMimulusmonkeyflowernatural variationpigmentationreaction-diffusion

Identifiers

PMID32155414
PMCPMC7156294
OpenAlexW3007422624

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.