Evidence map›Paper›PMID 32155338›Full record

ArticleJournal of the American Chemical Society2020

AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides.

Amanda Acevedo-Jake, Andrew T Ball, Marzia Galli, Mikiembo Kukwikila, Mathieu Denis, Daniel G Singleton, Ali Tavassoli, Stephen M Goldup

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 41 citations in OpenAlex.

  1. Tangled Tail of Mechanically Interlocked Peptides.Journal of the American Chemical Society · 2026
    Review
  2. Article
  3. Organic Cage Rotaxanes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Conditionally Activated ("Caged") Oligonucleotides.Molecules (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Amanda Acevedo-JakeChemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K.
Andrew T BallChemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K.
Marzia GalliChemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K.
Mikiembo KukwikilaChemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K.
Mathieu DenisChemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K.
Daniel G SingletonATDBio Ltd, School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K.
Ali TavassoliChemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K.
Stephen M GoldupChemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, U.K.ORCID 0000-0003-3781-0464
University of Southampton · GB

Funding

Biotechnology and Biological Sciences Research Council BB/J001694/2Cancer Research UK 20185
6 · The paper itself

Abstract

We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.

Indexed as

AlkynesAzidesClick ChemistryCopperCycloaddition ReactionDNAMacrocyclic CompoundsOligonucleotidesRotaxanesAlkynesAzidesCopperDNAMacrocyclic CompoundsOligonucleotidesRotaxanes

Identifiers

PMID32155338
PMCPMC8016193
OpenAlexW3012286149

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.