ArticleCurrent eye research2020
Bilaminar Structure of the Human Optic Nerve Sheath.
Article in Current eye research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Sonographic optic nerve sheath diameter measurement for detecting intracranial hypertension in a suspected population: a systematic review and meta-analysis of diagnostic thresholds and influencing factors.Journal of neurology · 2026Pooled it
- Optic nerve sheath meningioma exhibits neural niche-associated transcriptomic features and rare copy number variation-linked evolution.Brain pathology (Zurich, Switzerland) · 2026Article
- Impact of gaze deviation on the optic nerve sheath diameter metric: A prospective interventional study.The ultrasound journal · 2026Article
- Derivative indices of optic nerve sheath diameter: a novel ultrasound-based approach for non-invasive intracranial pressure monitoring in neurocritical patients.Frontiers in neurology · 2026Article
- Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Gaze-Induced Optic Nerve Head Deformations Are Greater in High Myopia and Strains Increase With Axial Length.Investigative ophthalmology & visual science · 2025Article
- Finite Element Model of the Effect of Optic Nerve Sheath Anisotropy on Ocular Loading During Horizontal Duction.Bioengineering (Basel, Switzerland) · 2025Article
- Tensile properties of glaucomatous human sclera, optic nerve, and optic nerve sheath.Biomechanics and modeling in mechanobiology · 2024Article
- Analysis of Peripapillary Intrachoroidal Cavitation and Myopic Peripapillary Distortions in Polar Regions by Optical Coherence Tomography.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Material properties and effect of preconditioning of human sclera, optic nerve, and optic nerve sheath.Biomechanics and modeling in mechanobiology · 2021Article
- Bilaminar Mechanics of the Human Optic Nerve Sheath.Current eye research · 2020Article
- The Five Diaphragms in Osteopathic Manipulative Medicine: Myofascial Relationships, Part 2.Cureus · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
PURPOSE/
aimWe aimed to characterize the connective tissue microanatomy, elastin abundance, and fiber orientation in the human optic nerve sheath, also known as the optic nerve dura mater, for correlation with its biomechanical properties. MATERIALS AND
methodsSeven whole human orbits aged 4-93 years, and five isolated human optic nerve sheaths aged 26-75 years were formalin fixed, paraffin embedded, coronally sectioned, stained by Masson trichrome and van Gieson's elastin methods, and analyzed quantitatively for elastin fiber abundance and orientation. Elastin area fraction was defined as area stained for elastin divided by total area.
resultsWhile unilaminar in children, the adult ON sheath exhibited distinct inner and outer layers. Collagen was denser and more compact in the inner layer. Elastin area fraction was significantly greater at 6.0 ± 0.4% (standard error of mean) in the inner than outer layer at 3.6 ± 0.4% (
conclusionsThe adult human optic nerve sheath is bilaminar, with each layer containing elastin fibers oriented in multiple directions consistent with isotropic properties. Differences in laminar elastin density and orientation may reflect greater tensile loading in the inner than in the outer layer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.