ArticleJBRA assisted reproduction2020
Taurine induces autophagy and inhibits oxidative stress in mice Leydig cells.
Article in JBRA assisted reproduction, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Do Sex and Gender Interact with the Biological Actions of Taurine? A Critical Rereading of the Literature.International journal of molecular sciences · 2025Review
- A narrative review on inflammaging and late-onset hypogonadism.Frontiers in endocrinology · 2024Review
- Taurine alleviates oxidative stress in porcine mammary epithelial cells by stimulating the Nrf2-MAPK signaling pathway.Food science & nutrition · 2023Article
- The role of taurine in male reproduction: Physiology, pathology and toxicology.Frontiers in endocrinology · 2023Review
- Protective role of taurine against oxidative stress (Review).Molecular medicine reports · 2021Review
- The modulatory effect of taurine on benzo (a) pyrene-induced hepatorenal toxicity.Toxicology research · 2021Article
- Downregulation of miR-200a Protects Mouse Leydig Cells Against Triptolide by Triggering Autophagy.Drug design, development and therapy · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study evaluated taurine (TAU) effects on autophagy, apoptosis and oxidative stress in mice Leydig TM3 cells.
methodsWe treated TM3 cells with TAU (100 µg/mL) or 3-Methyladenine (3-MA, an autophagy inhibitor) for 24 h, and assessed cell viability, testosterone level, oxidative stress, apoptosis, and autophagy.
resultsThe results showed that TAU markedly increased cell viability, testosterone levels, expression of autophagy-related genes and percentage of LC3-II-positive cells. TAU significantly reduced malondialdehyde (MDA) contents and reactive oxygen species (ROS) levels and increased the activities of SOD (superoxide dismutase) and CAT (Catalase) enzymes in the TM3 cells. TAU in the presence of autophagy inhibitor (3-MA) increased oxidative stress and decreased testosterone levels.
conclusionThe results showed that autophagy might be involved in TAU-increased testosterone levels in mice Leydig TM3 cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.