Evidence map›Paper›PMID 32154964›Full record

ArticleCancer science2020

Folate-appended cyclodextrin carrier targets ovarian cancer cells expressing the proton-coupled folate transporter.

Shinichi Saito, Yoshihiro Koya, Hiroaki Kajiyama, Mamoru Yamashita, Fumitaka Kikkawa, Akihiro Nawa

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shinichi SaitoDepartment of Obstetrics and Gynecology Collaborative Research, Bell Research Center, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID https://orcid.org/0000-0002-9962-3819
Yoshihiro KoyaDepartment of Obstetrics and Gynecology Collaborative Research, Bell Research Center, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hiroaki KajiyamaDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Mamoru YamashitaBell Research Center for Reproductive Health and Cancer, Medical Corporation Kishokai, Aichi, Japan.
Fumitaka KikkawaDepartment of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Akihiro NawaDepartment of Obstetrics and Gynecology Collaborative Research, Bell Research Center, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kishokai Medical Corporation · JPNagoya University · JP

Funding

Ministry of Education, Culture, Sports, Science and Technology 16K15705Ministry of Education, Culture, Sports, Science and Technology 19K09751
6 · The paper itself

Abstract

Folate receptor alpha (FRα) is overexpressed in >80% of epithelial ovarian cancer (EOC). Accordingly, folate is attracting attention as a targeting ligand for EOC. For EOC patients, paclitaxel (PTX) is generally used as a first-line chemotherapeutic agent in combination with platinum-based drugs. Cyclodextrin (CyD) is a potential new formulation vehicle for PTX that could replace Cremophor-EL, a traditional formulation vehicle that causes significant side effects, including neutropenia. Several years ago, folate-appended β-CyD (Fol-c

Indexed as

AnimalsAntineoplastic Agentsbeta-CyclodextrinsCarcinoma, Ovarian EpithelialCell Line, TumorCell SurvivalDrug CarriersDrug Delivery SystemsFemaleFolate Receptor 1Folic AcidGene ExpressionHumansMiceMolecular StructureOvarian NeoplasmsAntineoplastic Agentsbeta-CyclodextrinsbetadexDrug CarriersFolate Receptor 1Folic AcidFOLR1 protein, humanPaclitaxelProton-Coupled Folate TransporterSLC46A1 protein, humancyclodextrindrug carrierfolate receptor alphaovarian cancerproton-coupled folate transporter

Identifiers

PMID32154964
PMCPMC7226238
OpenAlexW3010975312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.