Evidence map›Paper›PMID 32154933›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2020

IL-1β Drives Production of FGF-23 at the Onset of Chronic Kidney Disease in Mice.

Quiana McKnight, Sarah Jenkins, Xiuqi Li, Tracy Nelson, Arnaud Marlier, Lloyd G Cantley, Karin E Finberg, Jackie A Fretz

Open access · greenAbstract read
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  12. Review
  13. Regulation of FGF23: Beyond Bone.Current osteoporosis reports · 2021
    Review
  14. Article
  15. Review
  16. Upstream Regulators of Fibroblast Growth Factor 23.Frontiers in endocrinology · 2021
    Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Quiana McKnightDepartment of Internal Medicine (Nephrology), Yale University School of Medicine, New Haven, CT, USA.
Sarah JenkinsDepartment of Internal Medicine (Nephrology), Yale University School of Medicine, New Haven, CT, USA.
Xiuqi LiDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Tracy NelsonDepartment of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USA.
Arnaud MarlierDepartment of Internal Medicine (Nephrology), Yale University School of Medicine, New Haven, CT, USA.
Lloyd G CantleyDepartment of Internal Medicine (Nephrology), Yale University School of Medicine, New Haven, CT, USA.
Karin E FinbergDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Jackie A FretzDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-6605-869X
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Renal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI ARONSON, PETER S. · 2008 to 2022
$16.8M
Yale Cooperative Hematology Specialized Core CenterU54DK106857 · NIDDK · YALE UNIVERSITY · PI JOHN HWA, Diane S Krause · 2015 to 2026
$9.7M
Macrophage Function in Kidney RepairR01DK093771 · NIDDK · YALE UNIVERSITY · PI LLOYD G CANTLEY · 2012 to 2026
$3.9M
Regulation of Podocyte Differentiation by the Transcription Factor EBF1R00DK093711 · NIDDK · YALE UNIVERSITY · PI FRETZ, JACKIE · 2014 to 2016
$727k
American Heart Association-American Stroke Association 18PRE33960343NCATS NIH HHS UL1 TR001863NIDDK NIH HHS 5U54DK106857NIDDK NIH HHS P30 DK079310NIDDK NIH HHS P30DK079310NIDDK NIH HHS R00 DK093711NIDDK NIH HHS R00DK093711NIDDK NIH HHS R01 DK093771NIDDK NIH HHS U54 DK106857
6 · The paper itself

Abstract

FGF-23 has arisen as an early biomarker of renal dysfunction, but at the onset of chronic kidney disease (CKD), data suggest that FGF-23 may be produced independently of the parathyroid hormone (PTH), 1,25(OH)

Indexed as

Renal Insufficiency, ChronicTumor Necrosis Factor-alphaAnimalsFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsForkhead Transcription FactorsHumansInterleukin-1betaKidneyMaleMiceMineralsParathyroid HormonePhosphatesFGF23 protein, humanFgf23 protein, mouseFibroblast Growth Factor-23Fibroblast Growth FactorsForkhead Transcription FactorsFOXD1 protein, humanIL1B protein, mouseInterleukin-1betaMineralsParathyroid HormonePhosphatesTumor Necrosis Factor-alphaGENETIC ANIMAL MODELSOSTEOBLASTSOSTEOCYTESPTH/VIT D/FGF23

Identifiers

PMID32154933
PMCPMC7363582
OpenAlexW3012053026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.