Evidence map›Paper›PMID 32154839›Full record

ArticleBrain : a journal of neurology2020

The repeat variant in MSH3 is not a genetic modifier for spinocerebellar ataxia type 3 and Friedreich's ataxia.

Wai Yan Yau, Mafalda Raposo, Conceição Bettencourt, Robyn Labrum, João Vasconcelos, Michael H Parkinson, Paola Giunti, Nicholas W Wood, Manuela Lima, Henry Houlden

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain : a journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Wai Yan YauDepartment of Neuromuscular Diseases, Institute of Neurology, University College London, UK.
Mafalda RaposoFaculty of Sciences and Technology, University of Azores, Ponta Delgada, Portugal.
Conceição BettencourtThe Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.
Robyn LabrumNeurogenetics Unit, National Hospital for Neurology and Neurosurgery, London, UK.
João VasconcelosDepartment of Neurology, Hospital of Divino Espírito Santo, Ponta Delgada, Portugal.
Michael H ParkinsonAtaxia Centre, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
Paola GiuntiAtaxia Centre, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London, UK.
Nicholas W WoodDepartment of Neuromuscular Diseases, Institute of Neurology, University College London, UK.
Manuela LimaFaculty of Sciences and Technology, University of Azores, Ponta Delgada, Portugal.
Henry HouldenDepartment of Neuromuscular Diseases, Institute of Neurology, University College London, UK.

Funding

Medical Research Council G0601943Medical Research Council MR/N028767/1Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Friedreich AtaxiaMachado-Joseph DiseaseMyotonic DystrophyHumansMutS Homolog 3 ProteinPhenotypeTrinucleotide RepeatsMSH3 protein, humanMutS Homolog 3 Protein

Identifiers

PMID32154839
PMCPMC7174052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.