ArticleeLife2020
Representation of visual landmarks in retrosplenial cortex.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 120 citations in OpenAlex.
- MIMAS: An open-source microlens-array miniature microscope for accessible large-field cortical imaging in freely behaving mice.Science advances · 2026Article
- Anterior and posterior retrosplenial cortex form distinct visuospatial circuits in the mouse.Nature communications · 2026Article
- Cortex-wide characterization of decision-making neural dynamics during spatial navigation.Nature communications · 2026Article
- Place field dynamics in retrosplenial cortex compared to hippocampus.Progress in neurobiology · 2026Article
- Neural mechanisms of feature binding in working memory.Communications biology · 2026Article
- Widefield cortical activity and functional connectivity during motorized locomotion.Communications biology · 2026Article
- Evidence of allocentric spatial learning in male rats with large lesions of the hippocampus.PloS one · 2026Article
- A map of the cortical functional network mediating naturalistic navigation.bioRxiv : the preprint server for biology · 2025Article
- Theta Activity Supports Landmark-Based Correction of Naturalistic Human Path Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation.bioRxiv : the preprint server for biology · 2025Article
- Working memory expands shared task representations in cortex.bioRxiv : the preprint server for biology · 2025Article
- Spatial reasoning via recurrent neural dynamics in mouse retrosplenial cortex.Nature neuroscience · 2025Article
- Cortico-subcortical networks that determine behavioral memory renewal are redefined by noradrenergic neuromodulation.Scientific reports · 2025Article
- Dissection of the long-range circuit of the mouse intermediate retrosplenial cortex.Communications biology · 2025Article
- Representational similarity analysis reveals cue-independent spatial representations for landmarks and self-motion cues in human retrosplenial cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The retrosplenial cortical role in delayed spatial alternation.Neurobiology of learning and memory · 2024Article
- Egocentric neural representation of geometric vertex in the retrosplenial cortex.Nature communications · 2024Article
- Learning to use landmarks for navigation amplifies their representation in retrosplenial cortex.bioRxiv : the preprint server for biology · 2024Article
- Differential stability of task variable representations in retrosplenial cortex.Nature communications · 2024Article
- Retrosplenial inputs drive visual representations in the medial entorhinal cortex.Cell reports · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The process by which visual information is incorporated into the brain's spatial framework to represent landmarks is poorly understood. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-dependent behavioral task in which head-fixed mice learned the spatial relationship between visual landmark cues and hidden reward locations. Two-photon imaging revealed that these cues served as dominant reference points for most task-active neurons and anchored the spatial code in RSC. This encoding was more robust after task acquisition. Decoupling the virtual environment from mouse behavior degraded spatial representations and provided evidence that supralinear integration of visual and motor inputs contributes to landmark encoding. V1 axons recorded in RSC were less modulated by task engagement but showed surprisingly similar spatial tuning. Our data indicate that landmark representations in RSC are the result of local integration of visual, motor, and spatial information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.