Evidence map›Paper›PMID 32154769›Full record

ArticleJournal of the renin-angiotensin-aldosterone system : JRAAS

No effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intake.

Sigurdur T Sigurdsson, Peter Bie, Arne H Nielsen, Svend Strandgaard, Olaf B Paulson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the renin-angiotensin-aldosterone system : JRAAS. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sigurdur T SigurdssonDepartment of Nephrology, Copenhagen University Hospital at Herlev, Denmark.
Peter BieDepartment of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
Arne H NielsenDepartment of Nephrology, Copenhagen University Hospital at Herlev, Denmark.
Svend StrandgaardDepartment of Nephrology, Copenhagen University Hospital at Herlev, Denmark.
Olaf B PaulsonNeurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Denmark.ORCID https://orcid.org/0000-0001-7712-8596
Herlev Hospital · DKUniversity of Copenhagen · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoregulation of cerebral blood flow (CBF) denotes that CBF is constant despite fluctuation of blood pressure within wide limits. Inhibition of the renin-angiotensin system (RAS) is known to decrease the lower and upper limits of CBF autoregulation. We have previously shown that this includes inhibition by the angiotensin receptor blocker (ARB) candesartan. In the present study we investigated the influence of the ARB candesartan on the lower limit of CBF autoregulation in two groups of Sprague-Dawley rats, on high (4.0% Na

Indexed as

Diet, Sodium-RestrictedAngiotensin II Type 1 Receptor BlockersAnimalsBenzimidazolesBiphenyl CompoundsBlood PressureCerebrovascular CirculationHomeostasisMaleRatsRats, Sprague-DawleyReninSodium, DietaryTetrazolesAngiotensin II Type 1 Receptor BlockersBenzimidazolesBiphenyl CompoundscandesartanReninSodium, DietaryTetrazolesautoregulationcerebral blood flowlaser Doppler flow measurementRenin–angiotensin systemsodium intake

Identifiers

PMID32154769
PMCPMC6732866
OpenAlexW2971931397

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.