ArticleACS sensors2020
Electrochemical Detection of NT-proBNP Using a Metalloimmunoassay on a Paper Electrode Platform.
Article in ACS sensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 88 citations in OpenAlex.
- Directional conjugation of monoclonal antibodies to nanoparticles using metal-free click chemistry.Nature protocols · 2026Review
- Size Effects of Silver Nanoparticles and Magnetic Beads on Silver-Gold Galvanic Exchange in Aptamer-Based Electrochemical Assays.Biosensors · 2025Article
- Advanced Nanomaterial-Based Biosensors for N-Terminal Pro-Brain Natriuretic Peptide Biomarker Detection: Progress and Future Challenges in Cardiovascular Disease Diagnostics.Nanomaterials (Basel, Switzerland) · 2024Review
- Article
- LSPR-Based Aptasensor for Rapid Urinary Detection of NT-proBNP.Biosensors · 2023Article
- Signaling strategies of silver nanoparticles in optical and electrochemical biosensors: considering their potential for the point-of-care.Mikrochimica acta · 2023Review
- One-Step Photochemical Immobilization of Aptamer on Graphene for Label-Free Detection of NT-proBNP.Biosensors · 2022Article
- Paper Biosensor for the Detection of NT-proBNP Using Silver Nanodisks as Electrochemical Labels.Nanomaterials (Basel, Switzerland) · 2022Article
- Plastic-based lateral flow immunoassay device for electrochemical detection of NT-proBNP.The Analyst · 2022Article
- Detection Efficiency of Ag Nanoparticle Labels for a Heart Failure Marker Using Linear and Square-Wave Anodic Stripping Voltammetry.Biosensors · 2022Article
- Electroanalytical point-of-care detection of gold standard and emerging cardiac biomarkers for stratification and monitoring in intensive care medicine - a review.Mikrochimica acta · 2022Review
- Ag nanoparticles outperform Au nanoparticles for the use as label in electrochemical point-of-care sensors.Analytical and bioanalytical chemistry · 2022Article
- Dual-Shaped Silver Nanoparticle Labels for Electrochemical Detection of Bioassays.ACS applied nano materials · 2021Article
- Antibody affinity as a driver of signal generation in a paper-based immunoassay for Ebola virus surveillance.Analytical and bioanalytical chemistry · 2021Article
- Effect of Serum on Electrochemical Detection of Bioassays Having Ag Nanoparticle Labels.ACS sensors · 2021Article
- Laser-Induced Carbon Electrodes in a Three-Dimensionally Printed Flow Reactor for Detecting Lead Ions.ACS omega · 2021Article
- Zeolite-iron oxide nanocomposite from fly ash formed a 'clubbell' structure: integration of cardiac biocapture macromolecules in serum on microelectrodes.Mikrochimica acta · 2021Article
- Silver Nanocubes as Electrochemical Labels for Bioassays.ACS sensors · 2021Article
- Thin Film Electrodes for Anodic Stripping Voltammetry: A Mini-Review.Frontiers in chemistry · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In this paper, we demonstrate an electrochemical method for detection of the heart failure biomarker, N-terminal prohormone brain natriuretic peptide (NT-proBNP). The approach is based on a paper electrode assembly and a metalloimmunoassay; it is intended for eventual integration into a home-use sensor. Sensing of NT-proBNP relies on the formation of a sandwich immunoassay and electrochemical quantification of silver nanoparticle (AgNP) labels attached to the detection antibodies (Abs). There are four important outcomes reported in this article. First, compared to physisorption of the detection Abs on the AgNP labels, a 27-fold increase in signal is observed when a heterobifunctional cross-linker is used to facilitate this labeling. Second, the assay is selective in that it does not cross-react with other cardiac natriuretic peptides. Third, the assay forms in undiluted human serum (though the electrochemical analysis is carried out in buffer). Finally, and most important, the assay is able to detect NT-proBNP at concentrations between 0.58 and 2.33 nM. This performance approaches the critical NT-proBNP concentration threshold often used by physicians for risk stratification purposes: ∼0.116 nM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.