Evidence map›Paper›PMID 32154641›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

Memory T cell-mediated rejection is mitigated by FcγRIIB expression on CD8

Anna B Morris, David F Pinelli, Danya Liu, Maylene Wagener, Mandy L Ford

Open access · bronzeAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. CD8Nature communications · 2024
    Article
  6. Article
  7. FcγRIIB expressed on CD8Science translational medicine · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anna B MorrisDepartment of Surgery, Emory Transplant Center, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0002-6879-6370
David F PinelliDepartment of Surgery, Emory Transplant Center, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0003-4827-6885
Danya LiuDepartment of Surgery, Emory Transplant Center, Emory University School of Medicine, Atlanta, Georgia.
Maylene WagenerDepartment of Surgery, Emory Transplant Center, Emory University School of Medicine, Atlanta, Georgia.
Mandy L FordDepartment of Surgery, Emory Transplant Center, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0001-6736-4421
Emory University · US

Funding

Determinants of T Cell Fate in Transplantation ToleranceR01AI073707 · NIAID · EMORY UNIVERSITY · PI FORD, MANDY L · 2008 to 2021
$4.0M
Advanced Research Training in Transplantation ScienceT32AI070081 · NIAID · EMORY UNIVERSITY · PI Mandy L Ford · 2006 to 2026
$3.1M
Costimulatory and Coinhibitory Receptor Control of Alloreactive T Cell ResponsesR01AI104699 · NIAID · EMORY UNIVERSITY · PI FORD, MANDY L · 2013 to 2017
$2.1M
NIAID NIH HHS R01 AI073707NIAID NIH HHS R01 AI104699NIAID NIH HHS T32 AI070081
6 · The paper itself

Abstract

Donor-reactive memory T cells generated via heterologous immunity represent a potent barrier to long-term graft survival following transplantation because of their increased precursor frequency, rapid effector function, altered trafficking patterns, and reduced reliance on costimulation signals for activation. Thus, the identification of pathways that control memory T cell survival and secondary recall potential may provide new opportunities for therapeutic intervention. Here, we discovered that donor-specific effector/memory CD8

Indexed as

Graft SurvivalImmunologic MemoryAnimalsCD8-Positive T-LymphocytesGraft RejectionHumansMiceMice, Inbred C57BLanimal models: murinebasic (laboratory) research/sciencecostimulationimmune regulationimmunobiologyinfection and infectious agentsinfectious diseaselymphocyte biology

Identifiers

PMID32154641
PMCPMC7395896
OpenAlexW3012430037

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.