Evidence map›Paper›PMID 32154577›Full record

ArticleBritish journal of pharmacology2020

Source of dopamine in gastric juice and luminal dopamine-induced duodenal bicarbonate secretion via apical dopamine D

Xiao-Yan Feng, Jing-Ting Yan, Guang-Wen Li, Jing-Hua Liu, Rui-Fang Fan, Shi-Chao Li, Li-Fei Zheng, Yue Zhang, Jin-Xia Zhu

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Peripheral catecholamine systems: an evolutionary perspective.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Review
  5. Review
  6. Dopaminergic signalling in gastrointestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Pancreatic acinar cells utilize tyrosine to synthesize L-dihydroxyphenylalanine.Experimental biology and medicine (Maywood, N.J.) · 2021
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xiao-Yan FengDepartment of Physiology and Pathophysiology, School of Basic Medical Science, Capital Medical University, Beijing, China.
Jing-Ting YanDepartment of Physiology and Pathophysiology, School of Basic Medical Science, Capital Medical University, Beijing, China.
Guang-Wen LiDepartment of Physiology and Pathophysiology, School of Basic Medical Science, Capital Medical University, Beijing, China.
Jing-Hua LiuGrade 2017 Clinical Medicine, School of Basic Medical Science, Capital Medical University, Beijing, China.
Rui-Fang FanDepartment of Physiology and Pathophysiology, School of Basic Medical Science, Capital Medical University, Beijing, China.
Shi-Chao LiDepartment of Physiology and Pathophysiology, School of Basic Medical Science, Capital Medical University, Beijing, China.
Li-Fei ZhengDepartment of Physiology and Pathophysiology, School of Basic Medical Science, Capital Medical University, Beijing, China.
Yue ZhangDepartment of Physiology and Pathophysiology, School of Basic Medical Science, Capital Medical University, Beijing, China.
Jin-Xia ZhuDepartment of Physiology and Pathophysiology, School of Basic Medical Science, Capital Medical University, Beijing, China.ORCID 0000-0002-2871-2996
Capital Medical University · CN

Funding

Beijing Nature Science Foundation 7182014National Key Research and Development Program 2016YFC1302203National Natural Science Foundation of China 31500937National Natural Science Foundation of China 31871159National Natural Science Foundation of China 81570695
6 · The paper itself

Abstract

background and purposeDopamine protects the duodenal mucosa. Here we have investigated the source of dopamine in gastric juice and the mechanism underlying the effects of luminal dopamine on duodenal bicarbonate secretion (DBS) in rodents. EXPERIMENTAL APPROACH: Immunofluorescence, UPLC-MS/MS, gastric incubation and perfusion were used to detect gastric-derived dopamine. Immunofluorescence and RT-PCR were used to examine the expression of dopamine receptors in the duodenal mucosa. Real-time pH titration and pH KEY

resultsH CONCLUSION AND IMPLICATIONS: Dopamine in the gastric juice is derived from parietal cells and is secreted along with gastric acid. On arrival in the duodenal lumen, dopamine increased DBS via an apical D

Indexed as

BicarbonatesDopamineAnimalsChromatography, LiquidDuodenumGastric JuiceMicePhosphatidylinositol 3-KinasesQuinpiroleRatsReceptors, DopamineReceptors, Dopamine D1Tandem Mass SpectrometryBicarbonatesDopaminePhosphatidylinositol 3-KinasesQuinpiroleReceptors, DopamineReceptors, Dopamine D1

Identifiers

PMID32154577
PMCPMC7312307
OpenAlexW3012349700

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.