ArticleKidney international reports2020
A Systematic Review and Meta-Analysis of Depression and Protein-Energy Wasting in Kidney Disease.
Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global prevalence of depression in chronic kidney disease: a systematic review and meta-analysis.Journal of nephrology · 2024Pooled it
- Effects of progressive muscle relaxation exercises on the vital signs and fatigue in kidney transplant patients: a randomized controlled trial.International urology and nephrology · 2024Trial
- Trial
- Design and Baseline Characteristics of CONCORD, a Trial of Novel Therapies for Depression in CKD.Kidney international reports · 2026Article
- Treating depression in dialysis patients: pharmacological and non-pharmacological approaches.Clinical kidney journal · 2026Review
- Biological and Metabolic Correlates of Psychological Resilience in Maintenance Hemodialysis: An Exploratory Gender-Based Study.Medicina (Kaunas, Lithuania) · 2026Article
- Depression inventory for maintenance hemodialysis patients: a cross-cultural adaptation and psychometric evaluation in Turkey.BMC nephrology · 2026Article
- The Impact of the CALLY Index on All-Cause Mortality in Patients With Depression: A Longitudinal Analysis Using NHANES Data.Health science reports · 2026Article
- Biochemical Associations with Depression, Anxiety, and Stress in Hemodialysis: The Role of Albumin, Calcium, and βBiomedicines · 2025Article
- Monomeric CRP and negative acute phase proteins, but not pentameric CRP, as biomarkers of major depression and MDMD.Acta neuropsychiatrica · 2025Article
- Chronic kidney disease is associated with incident depression requiring treatment: a retrospective cohort study.Clinical kidney journal · 2025Article
- Five Things to Know About Depression in Hemodialysis.Canadian journal of kidney health and disease · 2024Article
- Development and Validation of a Nomogram Model for Accurately Predicting Depression in Maintenance Hemodialysis Patients: A Multicenter Cross-Sectional Study in China.Risk management and healthcare policy · 2024Article
- Screening of key genes in the pathogenesis of muscle atrophy in CKD-PEW children based on RNA sequencing.BMC medical genomics · 2023Article
- Inflammatory Determinants and Associated Morbidity in Hemodialysis Patients.Journal of personalized medicine · 2023Article
- Sex difference in the associations among risk factors with depression in a large Taiwanese population study.Frontiers in public health · 2023Article
- Decreased Intracellular to Total Body Water Ratio and Depressive Symptoms in Patients with Maintenance Hemodialysis.Psychology research and behavior management · 2023Article
- Article
- High neutrophil-to-lymphocyte ratio is a significant predictor of depressive symptoms in maintenance hemodialysis patients: a cross-sectional study.BMC psychiatry · 2022Article
- Fatigue in CKD: Epidemiology, Pathophysiology, and Treatment.Clinical journal of the American Society of Nephrology : CJASN · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionDepression comorbid with chronic disease may be mediated by inflammation. We sought to characterize relationships between inflammatory biomarkers and depressive symptoms in patients with chronic kidney disease and end-stage kidney disease.
methodsA systematic literature search was conducted by 2 authors up to March 19, 2019, for studies of patients with chronic kidney disease or end-stage kidney disease evaluating circulating inflammatory biomarkers associated with depression of chronic disease: albumin, C-reactive protein (CRP), high-sensitivity CRP, interleukin-6 (IL-6), tumor necrosis factor-α, and interleukin-1. Standardized mean differences in biomarkers between individuals with and without depression were computed and analyzed using mixed effects models. Correlations between biomarkers and the severity of depressive symptoms were computed.
resultsThirty-four studies (5652 participants) compared biomarkers between depressed and nondepressed individuals. Individuals with depression had lower albumin levels (standardized mean difference, -0.37; 95% confidence interval [CI], -0.61 to -0.13), higher CRP levels (standardized mean difference, 0.76; 95% CI, 0.16-1.37), and higher IL-6 levels (standardized mean difference, 0.42; 95% CI, 0.21-0.63). Studies were heterogeneous for albumin, CRP, high-sensitivity CRP, and tumor necrosis factor-α. Twenty-three studies (3047 participants) investigated correlations between biomarkers and depressive symptoms. The severity of depressive symptoms correlated with albumin (
conclusionLower albumin and higher IL-6 were associated with both the presence and severity of depression, CRP with the presence of depression, and high-sensitivity CRP with the severity of depressive symptoms. The effect of interventions to lower inflammation in patients with kidney disease and depression deserves investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.