ArticleKidney international reports2020
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Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
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Authors and funding
52 authors at 20 institutions in 1 country.
Barry I FreedmanDepartment of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Marva M Moxey-MimsDivision of Nephrology, Children's National Health System, Washington, DC, USA.
Amir A AlexanderDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Brad C AstorDepartment of Medicine, Division of Nephrology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Kelly A BirdwellDepartment of Medicine, Division of Nephrology and Hypertension, Vanderbilt University, Nashville, Tennessee, USA.
Donald W BowdenDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Gordon BowenLifebanc, Cleveland, Ohio, USA.
Jonathan BrombergDepartment of Surgery, Division of Transplantation, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Timothy E CravenDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Darshana M DadhaniaDivision of Nephrology, Weill Cornell Medicine, New York, New York, USA.
Jasmin DiversDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Mona D DoshiDivision of Nephrology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Elling EidboAssociation of Organ Procurement Organizations, Vienna, Virginia, USA.
Alessia FornoniKatz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Drug Discovery Center, University of Miami Miller School of Medicine, Miami, Florida, USA.
Michael D GautreauxHuman Leukocyte Antigen/Immunogenetics and Immunodiagnostics Laboratories, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Rasheed A GbadegesinDepartment of Pediatrics, Division of Nephrology, Duke University School of Medicine, Durham, North Carolina, USA.
Patrick O GeeAPOLLO Community Advisory Council, Cleveland Clinic, Cleveland, Ohio, USA.
Giselle GuerraKatz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Drug Discovery Center, University of Miami Miller School of Medicine, Miami, Florida, USA.
Chi-Yuan HsuDepartment of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, California, USA.
Ana S IltisCenter for Bioethics, Health and Society, Department of Philosophy, Wake Forest University, Winston-Salem, North Carolina, USA.
Nichole JeffersonAPOLLO Steering Committee, APOLLO Community Advisory Council, Dallas, Texas, USA.
Bruce A JulianDepartment of Medicine, Division of Nephrology, University of Alabama School of Medicine in Birmingham, Birmingham, Alabama, USA.
David K KlassenUnited Network for Organ Sharing, Office of the Chief Medical Officer, Richmond, Virginia, USA.
Patrick P KotyDepartment of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Carl D LangefeldDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Krista L LentineDepartment of Medicine, Center for Abdominal Transplantation, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Lijun MaDepartment of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Roslyn B MannonDepartment of Medicine, Division of Nephrology, University of Alabama School of Medicine in Birmingham, Birmingham, Alabama, USA.
Madhav C MenonDepartment of Nephrology, Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sumit MohanDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, New York, USA.
J Brian MooreInstitutional Review Board, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Barbara MurphyDepartment of Nephrology, Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kenneth A NewellDepartment of Surgery, Division of Transplantation, Emory University School of Medicine, Atlanta, Georgia, USA.
Jonah OdimTransplantation Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Mariella Ortigosa-GogginsKatz Family Division of Nephrology and Hypertension, Peggy and Harold Katz Drug Discovery Center, University of Miami Miller School of Medicine, Miami, Florida, USA.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Meyeon ParkDepartment of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, California, USA.
Afshin ParsaDivision of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Stephen O PastanDepartment of Medicine, Renal Division, Emory University School of Medicine, Atlanta, Georgia, USA.
Emilio D PoggioDepartment of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Nishadi RajapakseNational Institutes of Health, National Institute on Minority Health and Health Disparities, Division of Scientific Programs, Bethesda, Maryland, USA.
Amber M Reeves-DanielDepartment of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Sylvia E RosasKidney and Hypertension Unit, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, USA.
Laurie P RussellDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Deirdre SawinskiRenal Electrolyte and Hypertension Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
S Carrie SmithDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Mitzie SpainhourDepartment of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Robert J StrattaDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Matthew R WeirDepartment of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
David M ReboussinDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Paul L KimmelDivision of Kidney, Urologic, and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Daniel C BrennanDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Wake Forest University · USUniversity of Miami · USCleveland Clinic · USEmory University · USIcahn School of Medicine at Mount Sinai · USNational Institute of Diabetes and Digestive and Kidney Diseases · USNational Institutes of Health · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Maryland, Baltimore · USAssociation of Organ Procurement Organizations · USChildren's National · USColumbia University · USDuke University · USHospital of the University of Pennsylvania · USJohns Hopkins University · USJoslin Diabetes Center · USNewYork–Presbyterian Hospital · USSaint Louis University · USUniversity of Michigan · US
Funding
Wake Forest APOLLO Scientific and Data Research CenterU01DK116041 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Nicholette D. Allred, BARRY Ira FREEDMAN · 2017 to 2026
$8.7MLiving Donor Extended Time Outcomes (LETO) StudyR01DK120551 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSU, CHI-YUAN, LENTINE, KRISTA L · 2019 to 2023
$3.9M12/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical CenterU01DK116043 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Chi-yuan Hsu, Meyeon Park · 2017 to 2026
$2.9MAPOL1 studies in kidney transplantation consortium clinical centers (ASK-CCC)U01DK116097 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Mona Devang Doshi, EMILIO DANIEL POGGIO · 2017 to 2026
$2.6MNorth East Consortium for Transplant outcomes in APOL1 kidney Recipients (NECTAR) Clinical CenterU01DK116100 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI Darshana Dadhania, Samira Farouk · 2017 to 2026
$2.5MImproving Quality and Access to Early Steps in Kidney TransplantationR01DK122701 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI PASTAN, STEPHEN, PATZER, RACHEL E · 2019 to 2022
$2.5MAPOL1 Long-Term Kidney Transplantation Outcomes-Consortium for the Responsible and Ethical Evaluation of Organ Donation (APOLLOCREED)Clinical CenterU01DK116042 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Daniel Conlon Brennan, Krista L Lentine · 2017 to 2026
$2.5M5/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical CenterU01DK116066 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Sumit Mohan, Deirdre Sawinski · 2017 to 2026
$2.5M1/13 ApoL1 Genotypes in Kidney Donors and Long-Term Outcomes in Kidney Transplant Recipients Clinical CenterU01DK116101 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALESSIA FORNONI, Mariella Cecilia Ortigosa-goggins · 2017 to 2026
$2.4MAPOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical CenterU01DK115997 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Gaurav Agarwal, ROSLYN B MANNON · 2017 to 2026
$2.4MStudying APOL1 Following Transplantation (SAF-T): the Emory APOLLO Clinical Center ConsortiumU01DK116099 · NIDDK · EMORY UNIVERSITY · PI KENNETH A. NEWELL, Stephen Pastan · 2017 to 2026
$2.3MLong-term Kidney Transplantation Outcomes Network (APOLLO) Clinical CenterU01DK116093 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kelly A Birdwell · 2017 to 2026
$2.3MNIDDK NIH HHS R01 DK120551NIDDK NIH HHS R01 DK122701NIDDK NIH HHS U01 DK115997NIDDK NIH HHS U01 DK116040NIDDK NIH HHS U01 DK116041NIDDK NIH HHS U01 DK116042NIDDK NIH HHS U01 DK116043NIDDK NIH HHS U01 DK116066NIDDK NIH HHS U01 DK116092NIDDK NIH HHS U01 DK116093NIDDK NIH HHS U01 DK116095NIDDK NIH HHS U01 DK116097NIDDK NIH HHS U01 DK116099NIDDK NIH HHS U01 DK116100NIDDK NIH HHS U01 DK116101NIDDK NIH HHS U01 DK116102NIMHD NIH HHS R01 MD014161
Abstract
introductionMuch of the higher risk for end-stage kidney disease (ESKD) in African American individuals relates to ancestry-specific variation in the apolipoprotein L1 gene (
methodsAPOLLO will evaluate outcomes from 2614 deceased kidney donor-recipient pairs, as well as additional living-kidney donor-recipient pairs and unpaired deceased-donor kidneys.
resultsThe United Network for Organ Sharing (UNOS), Association of Organ Procurement Organizations, American Society of Transplantation, American Society for Histocompatibility and Immunogenetics, and nearly all U.S. kidney transplant programs, organ procurement organizations (OPOs), and histocompatibility laboratories are participating in this observational study. APOLLO employs a central institutional review board (cIRB) and maintains voluntary partnerships with OPOs and histocompatibility laboratories. A Community Advisory Council composed of African American individuals with a personal or family history of kidney disease has advised the NIH Project Office and Steering Committee since inception. UNOS is providing data for outcome analyses.
conclusionThis article describes unique aspects of the protocol, design, and performance of APOLLO. Results will guide use of
Indexed as
African AmericansAPOL1chronic kidney diseasegraft failurekidney transplantationoutcomes
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