Evidence map›Paper›PMID 32154294›Full record

ReviewERJ open research2020

Caffeine in preterm infants: where are we in 2020?

Laura Moschino, Sanja Zivanovic, Caroline Hartley, Daniele Trevisanuto, Eugenio Baraldi, Charles Christoph Roehr

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ERJ open research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06401083 (The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate), which is not on this map. Cited by 67 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 5 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06401083 phase4recruitingnot on this mapstarted 2023, after this paper: background citation

The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate

TypeinterventionalSponsorSemmelweis UniversityRan2023 to 2028Enrolled226ConditionsApnea of Prematurity, Premature Birth, Respiratory FailureArmsCaffeine citrate
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 5 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Pooled it
  2. Administration time of caffeine in preterm infants: systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Pooled it
  3. Caffeine for apnea and prevention of neurodevelopmental impairment in preterm infants: systematic review and meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Pooled it
  4. Methylxanthine for the prevention and treatment of apnea in preterm infants.The Cochrane database of systematic reviews · 2023
    Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Laura MoschinoDept of Women's and Children's Health, University of Padua, Padua, Italy.
Sanja ZivanovicNewborn Services, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Caroline HartleyDept of Paediatrics, University of Oxford, Oxford, UK.
Daniele TrevisanutoDept of Women's and Children's Health, University of Padua, Padua, Italy.
Eugenio BaraldiDept of Women's and Children's Health, University of Padua, Padua, Italy.
Charles Christoph RoehrNewborn Services, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
University of Padua · ITUniversity of Oxford · GBJohn Radcliffe Hospital · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

The incidence of preterm birth is increasing, leading to a growing population with potential long-term pulmonary complications. Apnoea of prematurity (AOP) is one of the major challenges when treating preterm infants; it can lead to respiratory failure and the need for mechanical ventilation. Ventilating preterm infants can be associated with severe negative pulmonary and extrapulmonary outcomes, such as bronchopulmonary dysplasia (BPD), severe neurological impairment and death. Therefore, international guidelines favour non-invasive respiratory support. Strategies to improve the success rate of non-invasive ventilation in preterm infants include pharmacological treatment of AOP. Among the different pharmacological options, caffeine citrate is the current drug of choice. Caffeine is effective in reducing AOP and mechanical ventilation and enhances extubation success; it decreases the risk of BPD; and is associated with improved cognitive outcome at 2 years of age, and pulmonary function up to 11 years of age. The commonly prescribed dose (20 mg·kg

Identifiers

PMID32154294
PMCPMC7049734
OpenAlexW3009975326

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.