ArticleFrontiers in veterinary science2020
Comparative Plasma and Interstitial Fluid Pharmacokinetics of Meloxicam, Flunixin, and Ketoprofen in Neonatal Piglets.
Article in Frontiers in veterinary science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Comparing Pharmacokinetics of Meloxicam When Administered With a Needle-Free Injection Device Versus Needle-And-Syringe in Piglets.Journal of veterinary pharmacology and therapeutics · 2026Article
- Pharmacokinetics of Meloxicam in Different Animal Species: A Comprehensive Review.Veterinary sciences · 2024Review
- Efficacy and Safety of Lidocam Topical Gel (4% Lidocaine-0.3% Meloxicam) for Pain and Inflammation Management during Castration and Tail Docking in Piglets.Animals : an open access journal from MDPI · 2024Article
- An investigation of the use of ethyl chloride and meloxicam to decrease the pain associated with a single or double incision method of castration in piglets.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Pharmacokinetic/pharmacodynamic modeling of ketoprofen and flunixin at piglet castration and tail-docking.Journal of veterinary pharmacology and therapeutics · 2022Article
- Pharmacokinetics of combined administration of iron dextran with meloxicam or flunixin meglumine in piglets.The Canadian veterinary journal = La revue veterinaire canadienne · 2022Article
- Pharmacokinetics and bioavailability of ketoprofen when compounded with iron dextran for use in nursing piglets.The Canadian veterinary journal = La revue veterinaire canadienne · 2021Article
- Comparative effects of nonsteroidal anti-inflammatory drugs at castration and tail-docking in neonatal piglets.PloS one · 2021Article
- Plasma, urine and tissue concentrations of Flunixin and Meloxicam in Pigs.BMC veterinary research · 2020Article
- Optimal Methods of Documenting Analgesic Efficacy in Neonatal Piglets Undergoing Castration.Animals : an open access journal from MDPI · 2020Review
- Assessing Pain Control Efficacy of Meloxicam and Ketoprofen When Compounded with Iron Dextran in Nursing Piglets Using A Navigation Chute.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Piglet castration and tail-docking are routinely performed in the United States without analgesia. Pain medications, predominately non-steroidal anti-inflammatory drugs, are used in the EU/Canada to decrease pain associated with processing and improve piglet welfare, however, past studies have shown the efficacy and required dose remain controversial, particularly for meloxicam. This study assessed the pharmacokinetics of three NSAIDs (meloxicam, flunixin, and ketoprofen) in piglets prior to undergoing routine castration and tail-docking. Five-day-old male piglets (8/group) received one of 3 randomized treatments; meloxicam (0.4 mg/kg), flunixin (2.2 mg/kg), ketoprofen (3.0 mg/kg). Two hours post-dose, piglets underwent processing. Drug concentrations were quantified in plasma and interstitial fluid (ISF) and pharmacokinetic parameters were generated by non-compartmental analysis. Time to peak concentration (T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.