Evidence map›Paper›PMID 32154192›Full record

ReviewFrontiers in pediatrics2020

Life-Threatening Infectious Complications in Sickle Cell Disease: A Concise Narrative Review.

Dominik Ochocinski, Mansi Dalal, L Vandy Black, Silvana Carr, Judy Lew, Kevin Sullivan, Niranjan Kissoon

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Pooled it
  2. Does Sickle Cell Disease Protect against HIV Infection: A Systematic Review.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022
    Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Non-TyphoidalInfectious disease reports · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. More than malaria: ExploringCurrent research in parasitology & vector-borne diseases · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Prevalence, risk factors, and demographic insights of sickle cell hepatopathy in Omani adolescents and adults: A retrospective analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Dominik OchocinskiDepartment of Anesthesiology, University of Florida, Gainesville, FL, United States.
Mansi DalalDivision of Pediatric Hematology/Oncology, University of Florida, Gainesville, FL, United States.
L Vandy BlackDivision of Pediatric Hematology/Oncology, University of Florida, Gainesville, FL, United States.
Silvana CarrDivision of Pediatric Infectious Disease, University of Florida, Gainesville, FL, United States.
Judy LewDivision of Pediatric Infectious Disease, University of Florida, Gainesville, FL, United States.
Kevin SullivanDepartment of Anesthesiology, University of Florida, Gainesville, FL, United States.
Niranjan KissoonDepartment of Pediatrics, University of British Columbia and BC Children's Hospital, Vancouver, BC, Canada.
University of Florida · USBC Children's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sickle cell disease (SCD) results in chronic hemolytic anemia, recurrent vascular occlusion, insidious vital organ deterioration, early mortality, and diminished quality of life. Life-threatening acute physiologic crises may occur on a background of progressive diminishing vital organ function. Sickle hemoglobin polymerizes in the deoxygenated state, resulting in erythrocyte membrane deformation, vascular occlusion, and hemolysis. Vascular occlusion and increased blood viscosity results in functional asplenia and immune deficiency in early childhood, resulting in life-long increased susceptibility to serious bacterial infections. Infection remains a main cause of overall mortality in patients with SCD in low- and middle-income countries due to increased exposure to pathogens, increased co-morbidities such as malnutrition, lower vaccination rates, and diminished access to definitive care, including antibiotics and blood. Thus, the greatest gains in preventing infection-associated mortality can be achieved by addressing these factors for SCD patients in austere environments. In contrast, in high-income countries, perinatal diagnosis of SCD, antimicrobial prophylaxis, vaccination, aggressive use of antibiotics for febrile episodes, and the availability of contemporary critical care resources have resulted in a significant reduction in deaths from infection; however, chronic organ injury is problematic. All clinicians, regardless of their discipline, who assume the care of SCD patients must understand the importance of infectious disease as a contributor to death and disability. In this concise narrative review, we summarize the data that describes the importance of infectious diseases as a contributor to death and disability in SCD and discuss pathophysiology, prevalent organisms, prevention, management of acute episodes of critical illness, and ongoing care.

Indexed as

childrencritical careinfectionprophylaxissepsissickle cell diseasevaccination

Identifiers

PMID32154192
PMCPMC7044152
OpenAlexW3007821067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.