Evidence map›Paper›PMID 32154067›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2020

Targeted Delivery of Secretory Promelittin via Novel Poly(lactone-

Yu Zhou, Shenqi Zhang, Zeming Chen, Youmei Bao, Ann T Chen, Wendy C Sheu, Fuyao Liu, Zhaozhong Jiang, Jiangbing Zhou

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Biological profile of breast cancer brain metastasis.Acta neuropathologica communications · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. An Insight into Molecular Targets of Breast Cancer Brain Metastasis.International journal of molecular sciences · 2022
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Targeted Delivery of Secretory Promelittin via Novel Poly(lactone-Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Yu ZhouDepartment of Neurosurgery Yale University New Haven CT 06511 USA.
Shenqi ZhangDepartment of Neurosurgery Yale University New Haven CT 06511 USA.
Zeming ChenDepartment of Neurosurgery Yale University New Haven CT 06511 USA.
Youmei BaoDepartment of Neurosurgery Yale University New Haven CT 06511 USA.
Ann T ChenDepartment of Biomedical Engineering Yale University New Haven CT 06511 USA.
Wendy C SheuDepartment of Biomedical Engineering Yale University New Haven CT 06511 USA.
Fuyao LiuDepartment of Neurosurgery Yale University New Haven CT 06511 USA.
Zhaozhong JiangDepartment of Biomedical Engineering Yale University New Haven CT 06511 USA.ORCID https://orcid.org/0000-0002-1210-0274
Jiangbing ZhouDepartment of Neurosurgery Yale University New Haven CT 06511 USA.ORCID https://orcid.org/0000-0002-1201-5360
Yale University · USCentral South University · CN

Funding

Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT)U24NS107215 · NINDS · YALE UNIVERSITY · PI MARK Jay ALBERTS, Karen L Furie · 2018 to 2026
$3.0M
Improved glyburide therapy via acid- triggered release functional nanoparticles and therapeutic imagingR01NS110721 · NINDS · YALE UNIVERSITY · PI SHETH, KEVIN NAVIN, ZHOU, JIANGBING · 2019 to 2023
$1.9M
Novel grafted terpolymers for targeted delivery of CRISPR/Cas9- mediated precise genome editing to the brainUG3NS115597 · NINDS · YALE UNIVERSITY · PI ZHOU, JIANGBING · 2019 to 2022
$1.9M
Systemic gene therapy for glioblastomaR01NS095817 · NINDS · YALE UNIVERSITY · PI ZHOU, JIANGBING · 2016 to 2020
$1.8M
Novel grafted terpolymers for targeted delivery of CRISPR/Cas9- mediated precise genome editing to the brainUH3NS115597 · NINDS · YALE UNIVERSITY · PI ZHOU, JIANGBING · 2022 to 2022
$416k
NINDS NIH HHS R01 NS095817NINDS NIH HHS R01 NS110721NINDS NIH HHS U24 NS107215NINDS NIH HHS UG3 NS115597NINDS NIH HHS UH3 NS115597
6 · The paper itself

Abstract

Breast cancer brain metastases (BCBM) is a devastating disease with dismal prognosis. Although chemotherapy is widely used for clinical management of most tumors, it is often ineffective for BCBM. Therefore, alternative approaches for improved treatment of BCBM are in great demand. Here, an innovative gene therapy regimen is reported that is designed for effective treatment of BCBM. First, poly(lactone-

Indexed as

brain metastasisbreast cancergene therapymelittinpoly(lactone‐co‐β‐amino ester)

Identifiers

PMID32154067
PMCPMC7055583
OpenAlexW2999747079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.